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Titolo:
Anti-inflammatory effects of macrolides in lung disease
Autore:
Jaffe, A; Bush, A;
Indirizzi:
Great Ormond St Hosp Children NHS Trust, Dept Resp Med, London WC1N 3JH, England Great Ormond St Hosp Children NHS Trust London England WC1N 3JH England Royal Brompton & Harefield Natl Hlth Serv Trust, Dept Paediat Resp Med, London, England Royal Brompton & Harefield Natl Hlth Serv Trust London England England
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 6, volume: 31, anno: 2001,
pagine: 464 - 473
SICI:
8755-6863(200106)31:6<464:AEOMIL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL EPITHELIAL-CELLS; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; CHLAMYDIA-PNEUMONIAE INFECTION; BRONCHOALVEOLAR LAVAGE FLUID; STEROID-DEPENDENT ASTHMA; LOW-DOSE TROLEANDOMYCIN; NECROSIS-FACTOR-ALPHA; CYSTIC-FIBROSIS; DIFFUSE PANBRONCHIOLITIS; PSEUDOMONAS-AERUGINOSA;
Keywords:
cystic fibrosis; asthma; bronchiectasis; inflammation; macrolides; panbronchiolitis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Jaffe, A Great Ormond St Hosp Children NHS Trust, Dept Resp Med, Great Ormond St, London WC1N 3JH, England Great Ormond St Hosp Children NHS Trust Great Ormond St London England WC1N 3JH
Citazione:
A. Jaffe e A. Bush, "Anti-inflammatory effects of macrolides in lung disease", PEDIAT PULM, 31(6), 2001, pp. 464-473

Abstract

During the past five decades there has been increasing interest in the potential antiinflammatory effects of macrolide antibiotics. Low-dose macrolide therapy has dramatically increased survival in patients with diffuse panbronchiolitis, a disease with many similarities to cystic fibrosis (CF). This has led to further investigation into the potential use of macrolides in chronic lung diseases with an inflammatory component. This review summarizes the proposed anti-inflammatory mechanisms for this group of antibiotics, and examines the effect of macrolides on modulation of the inflammatory pathways, neutrophil function, bronchoconstriction, Pseudomonas biofilm, mucustheology, bacterial adherence, and multidrug-resistant protein. It discusses the current status of clinical studies in children with CF, bronchiectasis, and asthma. While there are much in vitro data for different proposed anti-inflammatory effects, randomized controlled clinical trials in childrenwith CF, bronchiectasis, and asthma are still just beginning. The benefitsand potential side effects need to be determined before routine use can beadvised. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:25:28