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Titolo:
Inspiratory flow reserve in boys with Duchenne muscular dystrophy
Autore:
De Bruin, PF; Ueki, J; Bush, A; Manzur, AY; Watson, A; Pride, NB;
Indirizzi:
Hammersmith Hosp, Imperial Coll, Sch Med, Dept Med, London, England Hammersmith Hosp London England oll, Sch Med, Dept Med, London, England Hammersmith Hosp, Imperial Coll, Sch Med, Dept Paediat, London, England Hammersmith Hosp London England Sch Med, Dept Paediat, London, England
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 6, volume: 31, anno: 2001,
pagine: 451 - 457
SICI:
8755-6863(200106)31:6<451:IFRIBW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY MUSCLE WEAKNESS; PULMONARY-FUNCTION; NORMAL VALUES; PRESSURES; LIMITATION; STRENGTH; ADULTS;
Keywords:
maximum inspiratory pressure; maximum inspiratory flow; tidal inspiratory flow; ventilatory reserve; muscle weakness; muscular dystrophy; neuromuscular disease; boys; pulmonary functions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pride, NB Hammersmith Hosp, Imperial Coll, Sch Med, Dept Med, Du Cane Rd, London, England Hammersmith Hosp Du Cane Rd London England Rd, London, England
Citazione:
P.F. De Bruin et al., "Inspiratory flow reserve in boys with Duchenne muscular dystrophy", PEDIAT PULM, 31(6), 2001, pp. 451-457

Abstract

Patients with advanced muscular dystrophy frequently develop ventilatory failure. Currently respiratory impairment usually is assessed by measuring vital capacity and the mouth pressure generated during a maximal inspiratorymaneuver (P-1,max), neither of which directly measures ventilatory capacity. We assessed inspiratory flow reserve in 26 boys [mean (SD) age 12.8 (3.8) years] with Duchenne muscular dystrophy (DMD) without ventilatory failureand in 28 normal boys [mean (SD) age 12.6 (1.9) years] by analyzing the ratio between the largest inspiratory flow during tidal breathing (V ' (1),max(t)) and during a forced Vital capacity maneuver (V ' (1),max((FVC))), (V ' (1),max(t)/V ' (1),max((FVC))). We have compared this ratio with the forced vital capacity (Nc) and P-1,max measured at functional residual capacity. Mean P-1,max was - 90(30)cmH(2)O, average 112% (range 57-179%) of predicted values in control boys and - 31(11)cmH(2)O, average 40% predicted values in DMD boys (control vs DMD, P < 0.001). FVC was reduced in DMD boys [59(20)% predicted values vs 86(10)% predicted values in controls, P < 0.01]. Absolute V ' (1),max((FVC)) was strongly related to FVC in both control and DMD boys; V ' (1),max((FVC)) (expressed as FVC(.)s(-1)) was not related to P-1,max in either group. The mean V-1,max(t)/V ' (1),max((FVC)) ratio was higher in DMD 0.22 (0.08) than in controls 0.12 (0.03) (P < 0.001) indicating a reduction in inspiratory flow reserve in DMD. Inspiratory flow reserve was within the normal range in 8 of 19 DMD patients with P-1,max less than 50% of predicted values. We conclude that measurement of inspiratory flow reserve (V ' (1),max(t)/V' (1),max((FVC)) ratio) provides a simple and direct assessment of dynamicinspiratory muscle function which is not replicated by static measurement of P-1,max or vital capacity and might be useful in assessment of respiratory impairment in boys with Duchenne muscular dystrophy. Follow-up studies are required to establish whether measures of inspiratory flow reserve are of clinical value in predicting subsequent ventilatory failure. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:11:20