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Titolo:
Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP)
Autore:
Takanashi, M; Mochizuki, H; Yokomizo, K; Hattori, N; Mori, H; Yamamura, Y; Mizuno, Y;
Indirizzi:
Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 iv, Sch Med, Dept Neurol, Tokyo 113, Japan Juntendo Univ, Sch Med, Div Pathol, Cent Lab Med Sci, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 Pathol, Cent Lab Med Sci, Tokyo 113, Japan Hiroshima Univ, Sch Med, Inst Hlth Sci, Hiroshima, Japan Hiroshima Univ Hiroshima Japan Sch Med, Inst Hlth Sci, Hiroshima, Japan
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 311 - 314
SICI:
1353-8020(200108)7:4<311:IAITSN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEME OXYGENASE-1; LOCALIZATION; DOPAMINE; DISEASE; PROTEIN;
Keywords:
iron; autosomal recessive juvenile parkinsonism (ARJP); Perls' stain; Parkinson's disease (PD);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Mochizuki, H Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 Dept Neurol, Tokyo 113, Japan
Citazione:
M. Takanashi et al., "Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP)", PARKINS R D, 7(4), 2001, pp. 311-314

Abstract

Autosomal recessive juvenile parkinsonism (ARJP) is a distinct clinical and genetic entity characterized by highly selective neuronal death in the substantia nigra (SN) and locus coeruleus neurons without Lewy body formation. The mechanism of neuronal death of ARJP is still unknown. Our study demonstrated that iron staining was more intense in ARJP than in both controls and sporadic Parkinson's disease (PD), and there were differences in the pattern of distribution of iron staining between ARJP and PD. In addition neurites of SN in ARJP showed intense iron staining. Thus, we postulate that oxidative stress may play an important role in the neurodegeneration that occurs in ARJP. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:08:43