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Titolo:
Alternating two finger tapping with contralateral activation is an objective measure of clinical severity in Parkinson's disease and correlates with PET [F-18]-DOPA Ki
Autore:
Pal, PK; Lee, CS; Samii, A; Schulzer, M; Stoessl, AJ; Mak, EK; Wudel, J; Dobko, T; Tsui, JKC;
Indirizzi:
Univ British Columbia, Vancouver Hosp & Hlth Sci Ctr, Ctr Neurodegenerat Disorders, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BCCanada V6T 2B5 ver, BC V6T 2B5, Canada
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 305 - 309
SICI:
1353-8020(200108)7:4<305:ATFTWC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PARKINSONISM; F-18 FLUORODOPA; DOPAMINE; BRAIN;
Keywords:
rating scale; finger tapping; Parkinson's disease; fluorodopa PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Tsui, JKC Univ British Columbia, Vancouver Hosp & Hlth Sci Ctr, Ctr Neurodegenerat Disorders, Purdy Pavil,2221 Westbrook Mall, Vancouver, BC V6T 2B5,Canada Univ British Columbia Purdy Pavil,2221 Westbrook Mall Vancouver BC Canada V6T 2B5
Citazione:
P.K. Pal et al., "Alternating two finger tapping with contralateral activation is an objective measure of clinical severity in Parkinson's disease and correlates with PET [F-18]-DOPA Ki", PARKINS R D, 7(4), 2001, pp. 305-309

Abstract

We explored an objective method of measuring clinical severity of Parkinson's disease. Eighty-six patients with PD and 136 healthy subjects were studied. We serially carried out four types of finger tapping (FT) using a computerized drum machine: (i) repetitive one-finger tapping with an index-finger (F1K1); (ii) one-finger tapping on two keys separated by 20 cm (F1K2); (iii) alternate tapping with index and middle fingers on two adjacent keys (F2K2); and (iv) F2K2 with contralateral activation (aF2K2). Analyses on FT included: (i) age and gender effects in healthy volunteers and Parkinson's disease; (ii) comparison between Parkinson patients and controls of similarage distribution; (iii) correlation with the Purdue Pegboard and Modified Columbia Scale in Disease; and (iv) in a subset of patients in whom PET scans were performed (n = 30), correlation with F-18-DOPA uptake constant (Ki). In healthy subjects, there was a negative age effect on FT scores and a gender effect, with males scoring higher than females. All FT scores were significantly lower in the Parkinson patients, correlated with Purdue Peg Board, and inversely with the duration of illness, and with the Modified Columbia Scale. The F-18-DOPA Ki correlated significantly with aF2K2 (p = 0.024), less so with PPB (p = 0.038), but not with the Modified Columbia Scale. We conclude that alternating two-finger tapping with contralateral hand activation is a simple, objective test for measuring the severity of Parkinson's disease. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:30:06