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Titolo:
Familial occurrence of Parkinson's disease in a community-based case-control study
Autore:
Kuopio, AM; Marttila, RJ; Helenius, H; Rinne, UK;
Indirizzi:
Jyvaskyla Cent Hosp, Dept Neurol, Jyvaskyla 40620, Finland Jyvaskyla Cent Hosp Jyvaskyla Finland 40620 ol, Jyvaskyla 40620, Finland Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Univ Turku, Dept Biostat, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ept Biostat, FIN-20520 Turku, Finland
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 4, volume: 7, anno: 2001,
pagine: 297 - 303
SICI:
1353-8020(200108)7:4<297:FOOPDI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL RISK-FACTORS; POSITRON EMISSION TOMOGRAPHY; AUTOSOMAL-DOMINANT; CIGARETTE-SMOKING; F-18 DOPA; ANTICIPATION; ONSET; TWINS; GENETICS; SIBLINGS;
Keywords:
Parkinson's disease; case-control study; familial occurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kuopio, AM Jyvaskyla Cent Hosp, Dept Neurol, Jyvaskyla 40620, Finland Jyvaskyla Cent Hosp Jyvaskyla Finland 40620 la 40620, Finland
Citazione:
A.M. Kuopio et al., "Familial occurrence of Parkinson's disease in a community-based case-control study", PARKINS R D, 7(4), 2001, pp. 297-303

Abstract

Purpose: To study the occurrence of Parkinson's disease (PD) in the relatives of parkinsonian patients (n = 119), and of their matched controls (n = 238). Scope: More patients reported a positive family history of PD in their first degree relatives, compared to their controls (OR 2.7, 95% CI 1.3-5.9), and the incidence of PD among those relatives was also significantly higher (OR 1.4, 95% CI 1.1-1.8). Conclusions: Familial occurrence of PD is not necessarily a sign of genetic mechanisms in the etiology of PD. Shared environment with common risk factors might be even more important. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:55:58