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Titolo:
Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells
Autore:
Mazzio, E; Huber, J; Darling, S; Harris, N; Soliman, KFA;
Indirizzi:
Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA Florida A&M Univ Tallahassee FL USA 32307 Sci, Tallahassee, FL 32307 USA
Titolo Testata:
NEUROTOXICOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 283 - 288
SICI:
0161-813X(200104)22:2<283:EOAOLA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; PARKINSONS-DISEASE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; OXIDATIVE STRESS; FREE-RADICALS; COMPLEX-I; MITOCHONDRIA; DEHYDROGENASE; GLUTATHIONE; INHIBITION;
Keywords:
MPP+; Parkinson's disease; antioxidants; coenzyme Q-10; N-acetyl-L-cysteine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Soliman, KFA Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA Florida A&M Univ Tallahassee FL USA 32307 ssee, FL 32307 USA
Citazione:
E. Mazzio et al., "Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells", NEUROTOXICO, 22(2), 2001, pp. 283-288

Abstract

The neuropathology associated with Parkinson's disease within and around the substantia nigra is thought to involve excessive production of free radicals, dopamine autoxidation, defects in the expression of glutathione peroxidase, alternated levels of reduced glutathione, alter-ed calcium homeostasis, excitotoxicity and genetic defects in mitochondrial complex I activity. While the neurotoxic mechanisms are vastly different for excitotoxins and N-methyl-4-phenylpyridinium ion (MPP+), both are thought to involve free radical production, compromised mitochondrial activity and excessive lipid peroxidation. In the present study, several dietary antioxidant compounds, monoamine oxidase inhibitors and ergogenic compounds were examined for protective action against neurotoxicity induced by L-glutamate (15 mM) ol MPP+-HCl (5 mM) iii a plastic adhering variant of murine pheochromocytoma cells. The results show no significant protective effects exhibited by azulene, (+)-catechin, curcumin, epigallocatechin gallate, green tea, morin, pygnogenol, silymarin, clove oil, garlic oil or rosemary extract. Compounds, which were effective in providing protection against L-glutamate-induced cell death, were coenzyme (O) under tilde -0, coenzyme (O) under tilde, L-deprenyl and N-acetyl-L-cysteine. Compounds, which provided protection against MPP+-HCl toxicity, were allopurinol, coenzyme (O) under tilde -10, L-deprenyl, N-acetyl-L-cystene and sesame oil. In both models, significant protection was achieved ill the presence of coenzyme (O) under tilde -10, L-deprenyl and N-acetyl-L-cysteine. These results indicate that the mechanism of cell deathin both of these toxicity models is moss likely not related to the destructive effects of free radicals. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:32:09