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Titolo:
Differential effects of chlorpromazine on ionotropic glutamate receptors in cultured rat hippocampal neurons
Autore:
Zarnowska, ED; Mozrzymas, JW;
Indirizzi:
Wroclaw Med Univ, Dept Biophys, PL-50368 Wroclaw, Poland Wroclaw Med UnivWroclaw Poland PL-50368 ophys, PL-50368 Wroclaw, Poland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 305, anno: 2001,
pagine: 53 - 56
SICI:
0304-3940(20010601)305:1<53:DEOCOI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; BRAIN DOPAMINE; NMDA RECEPTOR; SCHIZOPHRENIA; CHANNEL; DRUGS; HALOPERIDOL; INHIBITION; CURRENTS; DISEASE;
Keywords:
glutamate receptors; N-methyl-D-aspartate receptors; non-N-methyl-D-aspartate receptors; desensitization; patch-clamp; hippocampal neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Zarnowska, ED Wroclaw Med Univ, Dept Biophys, Chalubinskiego 10, PL-50368 Wroclaw, Poland Wroclaw Med Univ Chalubinskiego 10 Wroclaw Poland PL-50368
Citazione:
E.D. Zarnowska e J.W. Mozrzymas, "Differential effects of chlorpromazine on ionotropic glutamate receptors in cultured rat hippocampal neurons", NEUROSCI L, 305(1), 2001, pp. 53-56

Abstract

The effect of a widely used phenothiazine, chlorpromazine (CPZ) on ionotropic glutamate receptors was investigated using the patch-clamp technique incultured rat hippocampal neurons. The non-N-methyl-D-aspartate (NMDA) receptors were insensitive to CPZ. The current responses to NMDA showed a wide range of variability of both the rate and the extent of desensitization. The responses characterized by fast and profound desensitization were strongly inhibited by 30 muM CPZ. The effectiveness of block of NMDA responses wasclearly correlated with the apparent time constant of the desensitization onset. The extent of desenstitization was found to be increased by CPZ. We conclude that CPZ inhibits the NM DA receptors and propose that the sensibility to CPZ may depend both on the subunit composition and on the state of receptor modulation by intracellular factors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:54:23