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Titolo:
Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms
Autore:
Piggins, HD; Marchant, EG; Goguen, D; Rusak, B;
Indirizzi:
Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4H2, Canada Dalhousie Univ Halifax NS Canada B3H 4H2 hol, Halifax, NS B3H 4H2, Canada Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Dalhousie Univ, Dept Psychiat, Halifax, NS B3H 4H2, Canada Dalhousie UnivHalifax NS Canada B3H 4H2 iat, Halifax, NS B3H 4H2, Canada
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 305, anno: 2001,
pagine: 25 - 28
SICI:
0304-3940(20010601)305:1<25:PEOPAC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; SUPRACHIASMATIC NUCLEUS; RETINOHYPOTHALAMIC TRACT; CIRCADIAN-RHYTHMS; PACAP; PEPTIDE; GLUTAMATE; CLOCK;
Keywords:
suprachiasmatic nucleus; circadian pacemaker; neuropeptide; entrainment; retinohypothalamic tract;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Piggins, HD Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4H2, Canada Dalhousie Univ Halifax NS Canada B3H 4H2 , NS B3H 4H2, Canada
Citazione:
H.D. Piggins et al., "Phase-shifting effects of pituitary adenylate cyclase activating polypeptide on hamster wheel-running rhythms", NEUROSCI L, 305(1), 2001, pp. 25-28

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP38) is a putativeneurochemical of the main retinal input to the mammalian circadian pacemaker housed in the suprachiasmatic nucleus (SCN). We assessed the phase-resetting effects of microinjection of PACAP38 into the SCN region on hamster wheel-running rhythms. When administered during the middle of the subjective day, PACAP38 evoked large but transient phase advances (similar to 60 min),that were followed by small, steady-state phase delays. During the early subjective night, PACAP38 elicited small to moderate phase delays without any detectable concentration-dependence. Late in the subjective night, PACAP38 had no significant effects. Saline microinjection had no effect at any phase tested. These findings show that PACAP38 has small to moderate effects on the phase of the hamster SCN circadian pacemaker, including significant phase delays early in the subjective night. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:24:42