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Titolo:
Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats
Autore:
Ko, ML; Hu, DN; Ritch, R; Sharma, SC; Chen, CF;
Indirizzi:
Natl Taiwan Univ, Dept Physiol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 Dept Physiol, Taipei 10018, Taiwan Hsinchu Hosp, Dept Ophthalmol, Hsinchu, Taiwan Hsinchu Hosp Hsinchu Taiwan nchu Hosp, Dept Ophthalmol, Hsinchu, Taiwan New York Eye & Ear Infirm, Dept Ophthalmol, New York, NY 10003 USA New York Eye & Ear Infirm New York NY USA 10003 l, New York, NY 10003 USA New York Eye & Ear Infirm, Dept Pathol & Lab Med, New York, NY 10003 USA New York Eye & Ear Infirm New York NY USA 10003 d, New York, NY 10003 USA New York Med Coll, Dept Ophthalmol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 phthalmol, Valhalla, NY 10595 USA New York Med Coll, Dept Cell Biol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 Cell Biol, Valhalla, NY 10595 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 305, anno: 2001,
pagine: 139 - 142
SICI:
0304-3940(20010608)305:2<139:PORGCS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED INTRAOCULAR-PRESSURE; EXPERIMENTAL GLAUCOMA; AXONAL-TRANSPORT; MESSENGER-RNA; RECEPTOR TRKB; IN-VIVO; BDNF; DEATH; PROTECTION; NEURONS;
Keywords:
brain-derived neurotrophic factor; retinal ganglion cell; glaucoma; hypertensive eye;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, CF Natl Taiwan Univ, Dept Physiol, 1 Sect,1 Jen Ai Rd, Taipei 10018,Taiwan Natl Taiwan Univ 1 Sect,1 Jen Ai Rd Taipei Taiwan 10018 , Taiwan
Citazione:
M.L. Ko et al., "Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats", NEUROSCI L, 305(2), 2001, pp. 139-142

Abstract

We investigated the effect of brain-derived neurotrophic factor (BDNF) on retinal ganglion cell (RGC) survival after intraocular pressure (IOP) elevation at various time intervals. In adult Wistar rats, RGCs were labeled with 5% Fluorogold. Animals with 1.8-2.5-fold increase in IOP after cauterization of three episcleral vessels, were divided into three BDNF groups and three vehicle control groups, each receiving one, two or three injections. The RGC survival percentage on RGCs of the first, second and third injectionswere 93.9% (n = 7), 91.3% (n = 7), 82.7% (n = 5), respectively in BDNF groups; 91.6% (n = 6), 84.1% (n = 6) and 73.5% (n = 5), respectively in vehicle controls. The second and third injections of BDNF showed statistically significant survival effects. These findings demonstrated that BDNF has partial neuroprotection on RGCs in whole retina and enhances RGC survival in moderately chronic hypertensive eyes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 30/11/20 alle ore 12:33:03