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Titolo:
Psychopharmacological evidences for the involvement of muscarinic and nicotinic cholinergic receptors on sweet substance-induced analgesia in Rattus norvegicus
Autore:
Irusta, AEC; Savoldi, M; Kishi, R; Resende, GCC; Freitas, RL; Carvalho, AD; Coimbra, NC;
Indirizzi:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 305, anno: 2001,
pagine: 115 - 118
SICI:
0304-3940(20010608)305:2<115:PEFTIO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETIC MICE; ELECTRICAL-STIMULATION; PERIAQUEDUCTAL GRAY; SACCHARIN INTAKE; PAIN; RATS; ANTINOCICEPTION; RESPONSES; SEROTONIN; REDUCTION;
Keywords:
sweet substance-induced analgesia; tail-flick test; acetylcholine; muscarinic receptors; nicotinic receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Coimbra, NC Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto,SP, Brazil Univ Sao Paulo Ave Bandeirantes 3900 Ribeirao Preto SP Brazil BR-14049900 BC
Citazione:
A.E.C. Irusta et al., "Psychopharmacological evidences for the involvement of muscarinic and nicotinic cholinergic receptors on sweet substance-induced analgesia in Rattus norvegicus", NEUROSCI L, 305(2), 2001, pp. 115-118

Abstract

In order to investigate the effects of sweet substance intake on pain modulation, male albino Wistar rats weighing 180-200 g received either tap water or sucrose solutions (250 g/l) for 14 days as their only source of liquid. Each rat consumed an average of 15.6 g sucrose/day. Their tail withdrawallatencies in the tail-flick test (probably a spinal reflex) were measured immediately before and after this treatment. An analgesia index was calculated from the withdrawal latencies before and after treatment. The index (mean +/- SEM, N = 8) for the groups receiving sucrose solution plus saline (NaCl; 0.9%) for 14 days was 0.70 +/- 0.01. Atropine (1 and 2 mg/kg)-treated rats (N = 8) after intake of sucrose exhibited an analgesia index of 0.39 +/- 0.09 and 0.39 +/- 0.08, respectively, while mecamylamine (1 and 2 mg/kg)-treated rats (N = 10) after intake of sucrose had an index of -0.02 +/- 0.07 and 0.03 +/- 0.07, respectively. These results indicate that the effect of sucrose intake on nociceptive thresholds is controlled by neurotransmission of acetylcholine and depends on the nicotinic cholinergic receptors forits major analgesic effect, although muscarinic receptors were also involved in this antinociceptive process. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:59:26