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Titolo:
Astroglial function of schizophrenic brain: a study using lobotomized brain
Autore:
Niizato, K; Iritani, S; Ikeda, K; Arai, H;
Indirizzi:
Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Setagaya Ku, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Juntendo Univ, Sch Med, Dept Psychiat, Tokyo 1138421, Japan Juntendo UnivTokyo Japan 1138421 d, Dept Psychiat, Tokyo 1138421, Japan Tokyo Inst Psychiat, Dept Neuropathol, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 europathol, Tokyo 1568585, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1457 - 1460
SICI:
0959-4965(20010525)12:7<1457:AFOSBA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL DEVELOPMENT; CELL DISARRAY; HIPPOCAMPAL; CORTEX; LOBE;
Keywords:
astroglia; glial fibrillary acidic protein (GFAP); lobotomy; neurodevelopmental hypothesis; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Niizato, K Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Setagaya Ku, 2-1-1 Kamikitazawa, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp 2-1-1 Kamikitazawa Tokyo Japan 1560057
Citazione:
K. Niizato et al., "Astroglial function of schizophrenic brain: a study using lobotomized brain", NEUROREPORT, 12(7), 2001, pp. 1457-1460

Abstract

The neurodevelopmental hypothesis is now being recognized as one of the most useful hypothesis for schizophrenia, and by using it, abnormalities in protein associated with neuron growth or neuronal migration have been reported. From neuron-glia interrelations in the neural development, it is important to study the function of astroglia in the schizophrenic brain. In this study, we examined the neuropathological reaction of astroglia using lobotomized brains, and a significant decrease of astroglia after artificial histological damage was observed in schizophrenic brains. We speculated that this may be due to the latent vulnerability of the dynamic function of astroglia in schizophrenia. Astroglia plays a guidance role on migration and if astroglia has latent vulnerability, we speculate that younger neurons may not sufficiently migrate during development. In further investigation of the neurodevelopmental hypothesis of schizophrenia, it will be necessary to examine the function of astroglia. NeuroReport 12:1457-1460 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:33:31