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Titolo:
Tetrodotoxin-sensitive enhancement of inhibition in CAI pyramidal neuronesby nicotine
Autore:
Hulo, S; Muller, D;
Indirizzi:
Ctr Med Univ, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva Switzerland 4 ed Univ, CH-1211 Geneva 4, Switzerland
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1351 - 1354
SICI:
0959-4965(20010525)12:7<1351:TEOIIC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; ACETYLCHOLINE-RECEPTORS; SYNAPTIC TRANSMISSION; ORGANOTYPIC CULTURES; INTERNEURONS; ACTIVATION; SUBTYPES; DIVERSITY; RELEASE; NUCLEUS;
Keywords:
acetylcholine; di-hydro-beta-erythroidine; GABAergic transmission; hippocampus; inhibitory transmission; IPSC; methyllicaconitine; nicotinic receptors; spontaneous activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hulo, S Ctr Med Univ, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva Switzerland 4 CH-1211 Geneva 4, Switzerland
Citazione:
S. Hulo e D. Muller, "Tetrodotoxin-sensitive enhancement of inhibition in CAI pyramidal neuronesby nicotine", NEUROREPORT, 12(7), 2001, pp. 1351-1354

Abstract

Nicotine modulates excitatory and inhibitory transmission in the hippocampus by acting on receptors located on various cellular compartments. We report that nicotine, applied for 5-10 min at concentrations similar to those found during smoking (0.5-5 muM), resulted in all CAI pyramidal neurones in a marked, phasic and tonic increase in the frequency and amplitude of spontaneous inhibitory currents. This effect was fully prevented by pre-incubation with the sodium channel blocker tetrodotoxin and was partially inhibitedby the two nicotinic receptor antagonists methyllicaconitine (MLA) and dihydro-beta -erythroidine-(DH betaE). We conclude that, under conditions found during smoking, nicotine enhances inhibitory transmission, an effect exclusively mediated-through an enhancement of the firing rate of interneurones, without changes in spontaneous quantal release of GABA. NeuroReport 12:1351-1354. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 03:11:02