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Titolo:
Malonate-induced cortico-motoneuron death is attenuated by NT-4, but not by BDNF or NT-3
Autore:
Van Westerlaak, MGH; Bar, PR; Cools, AR; Joosten, EAJ;
Indirizzi:
UMC Utrecht, RMI Neurosci, Dept Expt Neurol, NL-3508 GA Utrecht, Netherlands UMC Utrecht Utrecht Netherlands NL-3508 GA -3508 GA Utrecht, Netherlands Univ Nijmegen, Dept Anat & Embryol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands nat & Embryol, Nijmegen, Netherlands Univ Nijmegen, Dept Psychoneuropharmacol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands europharmacol, Nijmegen, Netherlands
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1355 - 1358
SICI:
0959-4965(20010525)12:7<1355:MCDIAB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; IN-VITRO; NEUROTROPHIC FACTOR; MOTOR-NEURONS; SURVIVAL; RECEPTOR; VIVO; EXPRESSION; MECHANISMS; PROMOTE;
Keywords:
ALS; cortico-motoneurons; malonate; neurodegeneration; neurotrophins; organotypic slice culture; rat; SMI-32;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Joosten, EAJ UMC Utrecht, RMI Neurosci, Dept Expt Neurol, Room G02-314,POB85500, NL-3508 GA Utrecht, Netherlands UMC Utrecht Room G02-314,POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
M.G.H. Van Westerlaak et al., "Malonate-induced cortico-motoneuron death is attenuated by NT-4, but not by BDNF or NT-3", NEUROREPORT, 12(7), 2001, pp. 1355-1358

Abstract

Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we studied the neuroprotective effect of BDNF, NT-3, and NT-4 on the cell death of cortical motoneurons in an organotypic culture model after chronic mitochondrial inhibition with malonate. Our data show that NT-4 completely prevents: malonate-induced toxicity, whereas BDNF or NT-3 had no neuroprotective effect. In clinical trials for ALS, predominantly focussed on the survival of spinal motoneurons, BDNF has already been tested withdisappointing results; our results suggest that NT-4 may be a better neurotrophin to prevent motoneuron loss. NeuroReport 12:1355-1358. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:40:09