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Titolo:
Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis
Autore:
Sanyal, S; Krishnan, KS;
Indirizzi:
Tata Inst Fundamental Res, Dept Mol Biol, Bombay 400005, Maharashtra, India Tata Inst Fundamental Res Bombay Maharashtra India 400005 arashtra, India
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1363 - 1366
SICI:
0959-4965(20010525)12:7<1363:LCMIDR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHYLMALEIMIDE-SENSITIVE FACTOR; FUSION PROTEIN NSF; SYNAPTIC VESICLES; AXONAL GROWTH; IN-VIVO; INHIBITION; DOCKING; COMPLEX; MUTANTS; RELEASE;
Keywords:
development; Drosophila; neurogenesis; neurons; NSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sanyal, S Univ Arizona, MCB Dept, Room 514,Life Sci S, Tucson, AZ 85721 USA Univ Arizona Room 514,Life Sci S Tucson AZ USA 85721 Z 85721 USA
Citazione:
S. Sanyal e K.S. Krishnan, "Lethal comatose mutation in Drosophila reveals possible role for NSF in neurogenesis", NEUROREPORT, 12(7), 2001, pp. 1363-1366

Abstract

NSF is a cytosolic ATPase implicated in a variety of cellular functions including synaptic vesicle exocytosis. Here we report a lethal mutation in the Drosophila homolog of NSF (dNSFI). Lethality staging and rescue experiments with the wild type dNSFI transgene show that NSFI is critically requiredduring early larval stages and during late pupariation. Lethality in larval stages is associated with defects in neurogenesis as evidenced by an overall reduction in synapse size and synapse branching. Moreover, escaper adults, though showing abnormal seizure-like paralytic behavior, are normal in terms of synaptic transmission as assayed by electroretinograms. Taken together, these data indicate a role for NSF in neural growth and branching in addition to its documented role:in synaptic transmission. NeuroReport 12:1363-1366. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:25:20