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Titolo:
Antagonism of ORLI receptor produces an algesic effect in the rat formalintest
Autore:
Yamamoto, T; Sakashita, Y; Nozaki-Taguchi, N;
Indirizzi:
Chiba Univ, Sch Med, Dept Anesthesiol, Chuo Ku, Chiba 2608670, Japan ChibaUniv Chiba Japan 2608670 nesthesiol, Chuo Ku, Chiba 2608670, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 12, anno: 2001,
pagine: 1323 - 1327
SICI:
0959-4965(20010525)12:7<1323:AOORPA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS IN-VITRO; ORPHANIN-FQ; ORL(1) RECEPTOR; NOCICEPTIN/ORPHANIN FQ; INDUCED ANALGESIA; DORSAL HORN; SPINAL-CORD; PAIN; CONDUCTANCE; AGONIST;
Keywords:
formalin test; intrathecal injection; intracerebroventricular injection; J-113397; nociceptin; ORLI receptor; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, T Chiba Univ, Sch Med, Dept Anesthesiol, Chuo Ku, 1-8-1 Inohana,Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 a 2608670, Japan
Citazione:
T. Yamamoto et al., "Antagonism of ORLI receptor produces an algesic effect in the rat formalintest", NEUROREPORT, 12(7), 2001, pp. 1323-1327

Abstract

The authors investigated the role of endogenously released nociceptin (also known as orphanin FQ) in spinal and supraspinal nociceptive transmission during the rat formalin test by examining the effect of intrathecal and intracerebroventricular injection of J-113397, a non-peptidyl ORL1 receptor selective antagonist. When J-13397 was injected intrathecally or intracerebroventricularly 10 min before the formalin injection, it enhanced the agitation behavior induced by paw formalin injection. This suggested that paw formalin injection induced nocicetpin release in the spinal cord and the supraspinal. brain sites, that this endogenously released nociceptin produced an analgesic effect and that J-113397 antagonized this analgesic effect of nociceptin and produced an algesic effect in the rat formalin test. NeuroReport 12:1323-1327 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:07:22