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Titolo:
Anterior cingulate metabolism correlates with stroop errors in paranoid schizophrenia patients
Autore:
Nordahl, TE; Carter, CS; Salo, RE; Kraft, L; Baldo, J; Salamat, S; Robertson, L; Kusubov, N;
Indirizzi:
Univ Calif Berkeley, Lawrence Berkeley Lab, Ctr Funct Imaging, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Imaging, Berkeley, CA 94720 USA Univ Calif Davis, Dept Psychiat, Davis, CA USA Univ Calif Davis Davis CA USA Calif Davis, Dept Psychiat, Davis, CA USA Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh, PA USAUniv Pittsburgh Pittsburgh PA USA ychiat Inst & Clin, Pittsburgh, PA USA Univ Wisconsin, Ctr Clin Sci, Dept Surg Pathol, Madison, WI USA Univ Wisconsin Madison WI USA lin Sci, Dept Surg Pathol, Madison, WI USA VA No Calif Hlth Care Syst, Martinez, CA 94553 USA VA No Calif Hlth Care Syst Martinez CA USA 94553 , Martinez, CA 94553 USA Dept Vet Adm Med Ctr, Martinez, CA 94553 USA Dept Vet Adm Med Ctr Martinez CA USA 94553 ed Ctr, Martinez, CA 94553 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 139 - 148
SICI:
0893-133X(200107)25:1<139:ACMCWS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; EVENT-RELATED FMRI; SELECTIVE ATTENTION; IRRELEVANT INFORMATION; ALZHEIMERS-DISEASE; LOCUS COERULEUS; CORTEX; FLUORODEOXYGLUCOSE; NOREPINEPHRINE; HUMANS;
Keywords:
PET; regional glucose metabolism; anterior cingulate; stroop task; noradrenergic; dopaminergic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nordahl, TE Univ Calif Berkeley, Lawrence Berkeley Lab, Ctr Funct Imaging,55-121,1 Cyclotron Rd, Berkeley, CA 94720 USA Univ Calif Berkeley 55-121,1Cyclotron Rd Berkeley CA USA 94720
Citazione:
T.E. Nordahl et al., "Anterior cingulate metabolism correlates with stroop errors in paranoid schizophrenia patients", NEUROPSYCH, 25(1), 2001, pp. 139-148

Abstract

Using [O-15]-H2O PET Carter et al. (1997) reported that medicated patientswith schizophrenia performing computerized single trial Stroop (1935) showed a reduction in the anterior cingulate activation response to the more attention demanding, incongruent Stroop condition. In that study, both patients and controls also showed a direct correlation between anterior cingulateactivation and errors committed during incongruent trials of the task. In this study we follow up with an examination of paranoid schizophrenia outpatients and controls with very high resolution positron emission tomography (PET) and the longer half-life tracer [F-18]-fluorinated deoxyglucose (FDG)(Valk et al. 1990). All subjects (10 controls and 9 paranoid schizophreniapatients) were studied with FDG-PET while performing a computerized trial-by-trial version of the Stroop task during the uptake phase of the tracer (Carter et al. 1992). Results: As in previous studies using the single trialStroop, patients were able to perform the task but made move color-naming errors during incongruent trials than controls. The patients in the presentstudy showed a trend towards increased metabolic activity in the right anterior cingulate cortex. In the patient group, but not in controls, the anterior cingulate glucose metabolic rate correlated positively with the total incongruent trial errors. Conclusion: These results are consistent with thehypothesis that the anterior cingulate plays a performance-monitoring roleduring human cognition. This study does not rule out a reduction in error sensitivity in this region of the brain in schizophrenia, as other studies have suggested, however the data show that in unmedicated patients with theparanoid subtype this function is preserved to some extent. [Neuropsychopharmacology 25:139-148, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 02/04/20 alle ore 11:32:33