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Titolo:
Sex differences in cocaine-stimulated motor behavior: Disparate effects ofgonadectomy
Autore:
Walker, QD; Cabassa, J; Kaplan, KA; Li, ST; Haroon, J; Spohr, HA; Kuhn, CM;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Pharmacol, Durham, NC 27710 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 118 - 130
SICI:
0893-133X(200107)25:1<118:SDICMB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE-INDUCED BEHAVIORS; ELICITED ROTATIONAL BEHAVIOR; DOPAMINE RELEASE; GENDER DIFFERENCES; ESTROUS-CYCLE; STEREOTYPED BEHAVIOR; STRIATAL DOPAMINE; GONADAL-HORMONES; FEMALE RATS; LOCOMOTOR-ACTIVITY;
Keywords:
locomotion; rearing; stereotypy; gonadal hormones; psychostimulant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhn, CM Duke Univ, Med Ctr, Dept Pharmacol, 401 Bryan Res Bldg,Box 3813, Durham, NC 27710 USA Duke Univ 401 Bryan Res Bldg,Box 3813 Durham NC USA 27710 710 USA
Citazione:
Q.D. Walker et al., "Sex differences in cocaine-stimulated motor behavior: Disparate effects ofgonadectomy", NEUROPSYCH, 25(1), 2001, pp. 118-130

Abstract

Sex differences in biological substrates of drug use and addiction are poorly understood. The present study investigated sexual dimorphisms in motor behavior following acute cocaine administration (10, 20, or 40 mg/kg, i.p.). Cocaine increased stereotypy rating, horizontal and vertical activity in both sexes, and effects were always greater in females than males. A population analysis using data from multiple experiments indicated that horizontal activity scores were normally distributed in males but not in females. Gonadectomy induced disparate effects on cocaine-stimulated motor behavior. Population analysis indicated that castrated males exhibited more horizontalactivity and stereotypy than shams. Ovariectomy did not affect cocaine-stimulated stereotypy brit did attenuate horizontal activity in a subset of rats that had not been vaginally lavaged. In summary, gonadectomy effects were sex and behavioral topography specific and indicate that activational effects of gonadal hormones partially mediate the robust sex differences in cocaine-stimulated open-field behavior. [Neuropsychopharmacology 25:118-130, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:57:07