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Titolo:
Neuropeptide YY1 and Y-2 receptor mRNA expression in the prefrontal cortexof psychiatric subjects - Relationship of Y-2 subtype to suicidal behavior
Autore:
Caberlotto, L; Hurd, YL;
Indirizzi:
Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Sect, S-17176 Stockholm, Sweden
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 91 - 97
SICI:
0893-133X(200107)25:1<91:NYAYRM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; CEREBRAL-CORTEX; PEPTIDE-YY; RAT-BRAIN; DEPRESSED-PATIENTS; SOMATOSTATIN; IMMUNOREACTIVITY; LITHIUM; TACHYKININS; POLYPEPTIDE;
Keywords:
neuropeptide Y receptors; post-mortem; affective disorder; schizophrenia; aging; suicide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hurd, YL Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 7176 Stockholm, Sweden
Citazione:
L. Caberlotto e Y.L. Hurd, "Neuropeptide YY1 and Y-2 receptor mRNA expression in the prefrontal cortexof psychiatric subjects - Relationship of Y-2 subtype to suicidal behavior", NEUROPSYCH, 25(1), 2001, pp. 91-97

Abstract

It has been hypothesized that the neuropeptide Y (NPY) system is involved in the pathogenesis of mood disorder. In this study, Y-1 and Y-2 receptor mRNA expression levels were analyzed in the do dorsolateral prefrontal cortex of subjects affected with major depression, bipolar disorder, or schizophrenia and compared to normal controls. No significant alterations in Y-1 orY-2 mRNA expression levels were observed between the groups. However, the Y-2 mRNA expression was elevated in layer IV in subjects with suicide as a cause of death. For the Y-1 mRNA expression, there was a negative correlation with increasing subject age in the prefrontal cortex. Analysis of covariance revealed a significant elevation of the Y-1 mRNA expression levels in individuals with a current history of marijuana use but no of her drug. In summary, the current results suggest distinct alterations of the prefrontalY-1 and Y-2 neuronal populations in aging and suicide. [Neuropsychopharmacology 25:91-97, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 18/01/20 alle ore 13:41:22