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Titolo:
mu opiate receptor gene dose effects on different morphine actions: Evidence for differential in vivo mu receptor reserve
Autore:
Sora, I; Elmer, G; Funada, M; Pieper, J; Li, XF; Hall, FS; Uhl, GR;
Indirizzi:
NIDA, Mol Neurobiol Branch, IRP, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 iol Branch, IRP, NIH, Baltimore, MD 21224 USA UMAB, Maryland Psychiat Res Ctr, Catonsville, MD 21228 USA UMAB Catonsville MD USA 21228 Psychiat Res Ctr, Catonsville, MD 21228 USA Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Div Drug Dependence Res, Chiba, Japan Natl Ctr Neurol & Psychiat Chiba Japan rug Dependence Res, Chiba, Japan
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 41 - 54
SICI:
0893-133X(200107)25:1<41:MORGDE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-OPIOID RECEPTOR; G-PROTEIN ACTIVATION; KNOCKOUT MICE; INDUCED ANALGESIA; DEFICIENT MICE; MEDIATED ANTINOCICEPTION; PLACE PREFERENCE; AGONISTS; MECHANISMS; EXPRESSION;
Keywords:
transgenic knockout mice; locomotion; conditioned place preference; tolerance; physical dependence; lethality; self-administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Uhl, GR NIDA, Mol Neurobiol Branch, IRP, NIH, POB 5180,5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA POB 5180,5500 Nathan Shock Dr Baltimore MD USA 21224 1224 USA
Citazione:
I. Sora et al., "mu opiate receptor gene dose effects on different morphine actions: Evidence for differential in vivo mu receptor reserve", NEUROPSYCH, 25(1), 2001, pp. 41-54

Abstract

Homozygous transgenic knockout mice without mu -opioid receptors lack morphine-induced antinociception, locomotion, tolerance, physical dependence, and reward. mu receptors thus appear to play central roles in these morphineactions. Different levels of mu receptor expression are found in differenthumans and in different animal strains. In vitro studies indicate that some morphine responses persist after inactivation of as many as 90% of the initial mu receptor complement, while others are attenuated after inactivating many fewer receptors. Varying levels of mu receptor reserve could thus exist in different mu -expressing neuronal populations in vivo. Heterozygous mu receptor knockout mice express half of wild-type mu receptor levels. Tests of morphine actions in these mice reveal evidence for differing mu receptor reserves in brain circuits that mediate distinct opiate effects. Heterozygotes display attenuated locomotion, reduced morphine self-administration, intact tolerance, rightward shifts in morphine lethality dose/effect relationships, and variable effects on place preference compared to wild-type mice. They demonstrate full physical dependence, as measured by naloxone-precipitated abstinence following five days of morphine administration. Neuroadaptive changes in sites other than mu receptors could be involved in some of these results. Nevertheless, these data document substantial influences that individual differences in levels of mu receptor expression could exerton distinct opiate drug effects. They support the idea that functional mu receptor reserve differs among the diverse neuronal populations that mediate distinct properties of opiate drugs. [Neuropsychopharmacology 25:41-54, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:29:34