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Titolo:
Cocaine or selective block of dopamine transporters influences multisecondoscillations in firing rate in the globus pallidus
Autore:
Ruskin, DN; Bergstrom, DA; Baek, D; Freeman, LE; Walters, JR;
Indirizzi:
NINDS, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Therapeut Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 28 - 40
SICI:
0893-133X(200107)25:1<28:COSBOD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBTHALAMIC NUCLEUS; CA2+ OSCILLATIONS; 6-HYDROXYDOPAMINE-LESIONED RAT; RECEPTOR AGONISTS; UPTAKE INHIBITION; SQUIRREL-MONKEYS; SUBSTANTIA-NIGRA; GENE-EXPRESSION; BASAL GANGLIA; IN-VIVO;
Keywords:
cocaine; dopamine; GBR-12909; globus pallidus; NMDA receptor; oscillation; wavelet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Ruskin, DN 10 Ctr Dr,Room 5C103, Bethesda, MD 20892 USA 10 Ctr Dr,Room 5C103 Bethesda MD USA 20892 hesda, MD 20892 USA
Citazione:
D.N. Ruskin et al., "Cocaine or selective block of dopamine transporters influences multisecondoscillations in firing rate in the globus pallidus", NEUROPSYCH, 25(1), 2001, pp. 28-40

Abstract

Previous studies have shown that direct-acting dopamine agonists modulate the multisecond oscillations which are present in globus pallidus spike trains in vivo in awake rats. To investigate possible modulation by endogenousdopamine and by other monoamines, and by drugs with abuse potential, cocaine or selective monoamine uptake blockers were injected systemically duringextracellular recording of single globus pallidus neurons and the results analyzed with spectral and wavelet methods. Both cocaine and the selective dopamine uptake blocker GBR-12909 significantly shortened the period of multisecond oscillations, as well as increasing overall firing rate. Cocaine effects were blocked by dopamine antagonist pretreatment, as well as by N-methyl-D-aspartate receptor antagonist (MK-801) pretreatment. Desipramine andfluoxetine (blockers of norepinephrine and serotonin uptake, respectively)had no significant effects on multisecond oscillations. The results suggest that dopamine has a primary role among monoamines in modulating multisecond oscillations in globus pallidus activity, and that tonic dopaminergic and glutamatergic transmission is necessary for normal slow oscillatory function. [Neuropsychopharmacology 25:28-40, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:42:07