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Titolo:
GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder
Autore:
Benes, FM; Berretta, S;
Indirizzi:
McLean Hosp, Lab Struct Neurosci, Belmont, MA 02478 USA McLean Hosp Belmont MA USA 02478 b Struct Neurosci, Belmont, MA 02478 USA Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Neurosci Program, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 1 - 27
SICI:
0893-133X(200107)25:1<1:GIIFUS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; LOCAL-CIRCUIT NEURONS; GAMMA-AMINOBUTYRIC-ACID; MONKEY CEREBRAL-CORTEX; BENZODIAZEPINE RECEPTOR-BINDING; DOUBLE BOUQUET CELLS; POLYPEPTIDE-IMMUNOREACTIVE INTERNEURONS; PRIMARY SOMATOSENSORY CORTEX; DECARBOXYLASE MESSENGER-RNA; ANTERIOR CINGULATE CORTEX;
Keywords:
prefrontal; anterior cingulate; hippocampus; neuroleptics; dopamine; serotonin;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
252
Recensione:
Indirizzi per estratti:
Indirizzo: Benes, FM McLean Hosp, Lab Struct Neurosci, 115 Mill St, Belmont, MA 02478USA McLean Hosp 115 Mill St Belmont MA USA 02478 lmont, MA 02478 USA
Citazione:
F.M. Benes e S. Berretta, "GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder", NEUROPSYCH, 25(1), 2001, pp. 1-27

Abstract

A core component to corticolimbic circuitry is the GABAergic interneuron. Neuroanatomic studies conducted over the past century have demonstrated several subtypes of interneuron defined by characteristic morphological appearances in Golgi-stained preparations, More recently, both cytochemical and electrophysiological techniques have defined various subtypes of GABA neuronaccording to synaptic connections, electrophysiological properties and neuropeptide content. These cells provide both inhibitory and disinhibitory modulation of cortical and hippocampal circuits and contribute to the generation of oscillatory rhythms, discriminative information processing and gating of sensory information within the corticolimbic system. All of these functions are abnormal in schizophrenia. Recent postmortem studies have provided consistent evidence that a defect of GABAergic neurotransmission probablyplays a role in both schizophrenia and bipolar disorder. Many now believe that such a disturbance may be related to a perturbation of early development, one that may result in a disturbance of cell migration and the formation of normal lamination The ingrowth of extrinsic afferents, such as the mesocortical dopamine projections, may "trigger" the appearance of a defectiveGABA system, particularly under stressful conditions when the modulation of the dopamine system is likely to be altered. Based on the regional and subregional distribution of changes in GABA cells in schizophrenia and bipolar disorder, it has been postulated that the basolateral nucleus oft he amygdala may contribute to these abnormalities through an increased flow of excitatory activity. By using "partial" modeling, changes in the GABA system remarkably similar to those seen in schizophrenia and bipolar disorder have been induced in mt hippocampus. In the years to come, continued investigations of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease. [Neuropsychopharmacology 25:1-27, 2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 21/01/20 alle ore 01:00:49