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Titolo:
Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture
Autore:
Pierpaoli, C; Barnett, A; Pajevic, S; Chen, R; Penix, L; Virta, A; Basser, P;
Indirizzi:
NICHHD, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892NICHHD, NIH, Bethesda, MD 20892 USA NIMH, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, NIH, Bethesda, MD 20892 USA NINDS, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892NINDS, NIH, Bethesda, MD 20892 USA NIH, Ctr Informat Technol, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 H, Ctr Informat Technol, Bethesda, MD 20892 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 13, anno: 2001,
parte:, 1
pagine: 1174 - 1185
SICI:
1053-8119(200106)13:6<1174:WDCIWD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; TENSOR MRI; IN-VIVO; ANISOTROPY; ARTIFACTS; TISSUES; IMAGES;
Keywords:
diffusion; tensor; MRI; anisotropy; white matter; Wallerian; degeneration; brain; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Pierpaoli, C NICHHD, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 HD, NIH, Bethesda, MD 20892 USA
Citazione:
C. Pierpaoli et al., "Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture", NEUROIMAGE, 13(6), 2001, pp. 1174-1185

Abstract

This study investigates water diffusion changes in Wallerian degeneration. We measured indices derived from the diffusion tenser (DT) and TB-weightedsignal intensities in the descending motor pathways of patients with smallchronic lacunar infarcts of the posterior limb of the internal capsule on one side. We compared these measurements in the healthy and lesioned sides at different levels in the brainstem caudal to the primary lesion. We foundthat secondary white matter degeneration is revealed by a large reduction in diffusion anisotropy only in regions where fibers are arranged in isolated bundles of parallel fibers, such as in the cerebral peduncle. In regionswhere the degenerated pathway crosses other tracts, such as in the rostralpens, paradoxically there is almost no change in diffusion anisotropy, buta significant change in the measured orientation of fibers. The trace of the diffusion tenser is moderately increased in all affected regions. This allows one to differentiate secondary and primary fiber loss where the increase in trace is considerably higher. We show that DT-MRI is more sensitive than TS-weighted MRI in detecting Wallerian degeneration. Significant diffusion abnormalities are observed over the entire trajectory of the affected pathway in each patient. This finding suggests that mapping degenerated pathways noninvasively with DT-MRI is feasible. However, the interpretation ofwater diffusion data is complex and requires a priori information about anatomy and architecture of the pathway under investigation. In particular, our study shows that in regions where fibers cross, existing DT-MRI-based fiber tractography algorithms may lead to erroneous conclusion about brain connectivity.

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Documento generato il 23/01/20 alle ore 04:23:32