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Titolo:
Voxel-based mapping of brain hypometabolism in permanent amnesia with PET
Autore:
Aupee, AM; Desgranges, B; Eustache, F; Lalevee, C; de la Sayette, V; Viader, F; Baron, JC;
Indirizzi:
Univ Caen, INSERM, U320, F-14032 Caen, France Univ Caen Caen France F-14032 v Caen, INSERM, U320, F-14032 Caen, France Univ Caen, Dept Neurol, F-14032 Caen, France Univ Caen Caen France F-14032 iv Caen, Dept Neurol, F-14032 Caen, France Univ Cambridge, Dept Neurol, Cambridge, England Univ Cambridge CambridgeEngland ridge, Dept Neurol, Cambridge, England
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 13, anno: 2001,
parte:, 1
pagine: 1164 - 1173
SICI:
1053-8119(200106)13:6<1164:VMOBHI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALCOHOLIC KORSAKOFFS-SYNDROME; ALZHEIMERS-DISEASE; GLUCOSE-UTILIZATION; FUNCTIONAL NEUROANATOMY; MEMORY DYSFUNCTION; EPISODIC MEMORY; METABOLIC-RATE; SHORT-TERM; FDG-PET;
Keywords:
permanent amnesia; PET; FDG; hypometabolism network; (18) F-FDG; glucose utilization; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Baron, JC Addenbrookes Hosp, Dept Neurol, Box 165, Cambridge CB2 2QQ, England Addenbrookes Hosp Box 165 Cambridge England CB2 2QQ QQ, England
Citazione:
A.M. Aupee et al., "Voxel-based mapping of brain hypometabolism in permanent amnesia with PET", NEUROIMAGE, 13(6), 2001, pp. 1164-1173

Abstract

In this study, we used voxel-based mapping methods to compare the resting cerebral metabolic rate of glucose (CMRglc) measured with PET in five patients with permanent amnesia (three with chronic Wernicke-Korsakoff and two with postanoxia syndrome) to that of nine healthy age-matched subjects, We assessed (i) a group pattern of relative hypometabolism; and (ii) the consistency of this group pattern, if any, in individual subjects, according to etiology, The results from the group analysis documented that permanent amnesia is associated with hypometabolism in the thalamus, posterior cingulate cortex, and mesial prefrontal cortex (near the anterior cingulate gyrus), bilaterally, as well as in the left supramarginal and middle temporal gyri, The individual analysis showed that this group pattern was found in essentially each patient, regardless of the cause of amnesia. Thus, permanent amnesia is subtended by dysfunction in structures belonging to Papez/limbic circuits as well as in left-hemisphere areas typically concerned with verbal functions, probably through a mechanism of thalamocortical disconnection andpossibly involved in retrograde amnesia. The use of a voxel-based method allowed us to map a common network of synaptic dysfunction in a neuropsychological syndrome regardless of etiology, Our results indicate that this should be a powerful method in functional neuropsychology. (C) 2001 Academic Press.

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Documento generato il 06/04/20 alle ore 08:45:56