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Titolo:
Sexual dimorphism in the corpus callosum: Methodological considerations inMRI morphometry
Autore:
Bermudez, P; Zatorre, RJ;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 13, anno: 2001,
parte:, 1
pagine: 1121 - 1130
SICI:
1053-8119(200106)13:6<1121:SDITCC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-HANDERS; HEMISPHERIC-SPECIALIZATION; CEREBRAL-DOMINANCE; AREA MEASUREMENTS; PLANUM TEMPORALE; BRAIN VOLUME; SIZE; VARIABILITY; ASYMMETRY; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez, P McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 B4, Canada
Citazione:
P. Bermudez e R.J. Zatorre, "Sexual dimorphism in the corpus callosum: Methodological considerations inMRI morphometry", NEUROIMAGE, 13(6), 2001, pp. 1121-1130

Abstract

Studies of sexual dimorphism in the corpus callosum (CC) have employed a variety of methodologies for measurement and normalization but have yielded disparate results. The present work demonstrates how in some cases different manipulations of the same raw data, corresponding to different commonly used methodologies, produce discordant results. Midsagittal CC area was measured from magnetic resonance images (MRIs) of 137 young normal volunteers. Three strategies intended to normalize for average differences in brain size between the sexes, as well as five different normalization variables, were contrasted and evaluated. The stereotaxic method normalizes for intersubject differences in overall brain size by scaling MRIs into a standardized space. The ratio method uses one of five different indices of brain size anddivides it into CC area. The covariate method uses one of the indices as acovariate in statistical analyses. Male subjects show significantly largerabsolute total area, as well as anterior third and posterior midbody. However, in two of three normalization strategies, namely the stereotaxic and ratio methods, females show relatively larger total area, anterior midbody, and splenium, The covariate method did not show any significant differencesat the 0.05 level. Results suggest that different approaches to normalization and analysis are not necessarily equivalent and interchangeable. (C) 2001 Academic Press.

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Documento generato il 19/01/20 alle ore 20:35:05