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Titolo:
No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation
Autore:
Lindauer, U; Royl, G; Leithner, C; Kuhl, M; Gold, L; Gethmann, J; Kohl-Bareis, M; Villringer, A; Dirnagl, U;
Indirizzi:
Charite Hosp, Dept Expt Neurol, D-10098 Berlin, Germany Charite Hosp Berlin Germany D-10098 Expt Neurol, D-10098 Berlin, Germany
Titolo Testata:
NEUROIMAGE
fascicolo: 6, volume: 13, anno: 2001,
parte:, 1
pagine: 988 - 1001
SICI:
1053-8119(200106)13:6<988:NEFEDI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN-FUNCTION; SENSORY STIMULATION; INTRINSIC SIGNALS; SOMATOSENSORY STIMULATION; OXIDATIVE-METABOLISM; NEURONAL-ACTIVITY; BARREL CORTEX; VISUAL-CORTEX; NITRIC-OXIDE; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Lindauer, U Charite Hosp, Dept Expt Neurol, D-10098 Berlin, Germany Charite Hosp Berlin Germany D-10098 D-10098 Berlin, Germany
Citazione:
U. Lindauer et al., "No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation", NEUROIMAGE, 13(6), 2001, pp. 988-1001

Abstract

Using optical methods through a closed cranial window over the rat primarysensory cortex in chloralose/urethane-anesthetized rats we evaluated the time course of oxygen delivery and consumption in response to a physiological stimulus (whisker deflection). Independent methodological approaches (optical imaging spectroscopy, single fiber spectroscopy, oxygen-dependent phosphorescence quenching) were applied to different modes of whisker deflection (single whisker, full whisker pad). Spectroscopic data were evaluated using different algorithms (constant pathlength, differential pathlength correction). We found that whisker deflection is accompanied by a significant increase of oxygenated hemoglobin (oxy-Hb), followed by an undershoot. An early increase in deoxygenated hemoglobin (deoxy-Hb) proceeded hyperoxygenation when spectroscopic data were analyzed by constant pathlength analysis. However, correcting for the wavelength dependence of photon pathlength in brain tissue (differential pathlength correction) completely eliminated the increase in deoxy-sb. Oxygen-dependent phosphorescence quenching did not reproducibly detect early deoxygenation. Together with recent fMRI data, our results argue against significant early deoxygenation as a universal phenomenon in functionally activated mammalian brain. Interpreted with a diffusion-limited model of oxygen delivery to brain tissue our results are compatiblewith coupling between neuronal activity and cerebral blood flow throughoutstimulation, as postulated 110 years ago by C, Roy and C, Sherrington (1890, J. Physiol. 11:85-108), (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:59:32