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Titolo:
Modulation of potassium current and calcium influx by somatostatin in rod bipolar cells isolated from the rabbit retina via sst(2) receptors
Autore:
Petrucci, C; Resta, V; Fieni, F; Bigiani, A; Bagnoli, P;
Indirizzi:
Univ Pisa, Dipartimento Fisiol & Biochim G Moruzzi, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 ol & Biochim G Moruzzi, I-56127 Pisa, Italy Univ Modena & Reggio Emilia, Dipartimento Sci Biomed, I-41100 Modena, Italy Univ Modena & Reggio Emilia Modena Italy I-41100 , I-41100 Modena, Italy
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 6, volume: 363, anno: 2001,
pagine: 680 - 694
SICI:
0028-1298(200106)363:6<680:MOPCAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID JUNCTION POTENTIALS; CA2+-ACTIVATED K+ CHANNEL; CYTOSOLIC-FREE CALCIUM; SUBTYPE 2A EXPRESSION; SACCULAR HAIR-CELLS; VOLTAGE-GATED K+; RAT RETINA; IMMUNOHISTOCHEMICAL LOCALIZATION; GOLDFISH RETINA; PROTEIN-KINASE;
Keywords:
somatostatin sst(2) receptor; octreotide; sst(2) receptor antagonist; K+ currents; Ca2+ signalling; isolated rod bipolar cells; patch-clamp electrophysiology; Ca2+ imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Bagnoli, P Univ Pisa, Dipartimento Fisiol & Biochim G Moruzzi, Via San Zeno 31, I-56127 Pisa, Italy Univ Pisa Via San Zeno 31 Pisa Italy I-56127 56127 Pisa, Italy
Citazione:
C. Petrucci et al., "Modulation of potassium current and calcium influx by somatostatin in rod bipolar cells isolated from the rabbit retina via sst(2) receptors", N-S ARCH PH, 363(6), 2001, pp. 680-694

Abstract

Somatostatin (somatotropin release-inhibiting factor, SRIF) receptor subtypes are expressed by several retinal neurons, suggesting that SRIF acts at multiple levels of the retinal circuitry, although functional data on this issue are scarce. Of the SRIF receptors, the sst(2A) isoform is expressed by rod bipolar cells (RBCs) of the rabbit retina, and in isolated RBCs we studied the role of sst, receptors in modulating both K+ current (I-K) and the intracellular free [Ca2+] ([Ca2+](i)) using both voltage-clamp and Ca2+-imaging techniques. SRIF and octreotide (a SRIF agonist that binds to sst(2)receptors) inhibited that component of I-K corresponding to the activationof large-conductance, Ca2+- and voltage-dependent K+ channels (I-BK) and reduced the K+-induced [Ca2+](i) accumulation, suggesting that SRIF effects on I-BK may have been secondary to inhibition of Ca2+ channels. Octreotide effects on I-BK or On [Ca2+](i) accumulation were prevented by RBC treatment with L-Tyr(8)-Cyanamid 154806, a novel sst(2) receptor antagonist, indicating that SRIF effects were mediated by sst(2) receptor activation. The present data indicate that SRIF may modulate the information flow through second-order retinal neurons via an action predominantly at sst(2) receptors, contribute to the proposition that SRIF be added to the growing listof retinal neuromodulators, and suggest that one of its possible roles in the retina is to regulate transmitter release from RBCs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:47:37