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Titolo:
Inhibitory effect of SM-20550, an Na+/H+ exchange inhibitor, on accumulation of leukocytes in ischemia and reperfusion
Autore:
Yamada, K; Horikawa, N; Matsui, K; Yamamoto, S; Kawamura, N; Ohashi, N;
Indirizzi:
Sumitomo Pharmaceut Co Ltd, Res Ctr, Konohana Ku, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd Osaka Japan 5540022 Ku, Osaka 5540022, Japan
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 6, volume: 363, anno: 2001,
pagine: 597 - 603
SICI:
0028-1298(200106)363:6<597:IEOSAN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY OCCLUSION; MYOCARDIAL INFARCT SIZE; RAT HEARTS; NEUTROPHIL DEPLETION; INTRACELLULAR NA+; P-SELECTIN; INJURY; REDUCTION; ADHESION; ISCHEMIA/REPERFUSION;
Keywords:
Na+/H+ exchange; leukocyte; myocardial ischemia and reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, K Sumitomo Pharmaceut Co Ltd, Res Ctr, Konohana Ku, 1-98 Kasugadenaka 3 Chome, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd 1-98 Kasugadenaka 3 Chome Osaka Japan 5540022
Citazione:
K. Yamada et al., "Inhibitory effect of SM-20550, an Na+/H+ exchange inhibitor, on accumulation of leukocytes in ischemia and reperfusion", N-S ARCH PH, 363(6), 2001, pp. 597-603

Abstract

The effect of an Na+/H+ exchange inhibitor, SM-20550, on the adhesion, emigration and accumulation of leukocytes was studied in ischemia and reperfusion injury models using rat mesenteric venules or rabbit heart. Anesthetized rats underwent occlusion of the superior mesenteric artery (20 min) followed by reperfusion (60 min). After ischemia and reperfusion, the numbers ofadherent and emigrated leukocytes increased significantly. Bolus intravenous administration of SM-20550 reduced the numbers of adherent and emigratedleukocytes in a dose-dependent manner, with statistical significance at dosages >0.1 mg/kg. Anesthetized rabbits underwent occlusion of the coronary artery (30 min) followed by reperfusion (5 h). Intravenous administration of SM-20550 before ischemia significantly reduced the neutrophil accumulation in the area-at-risk by 46% and reduced the infarct size by 38%. These results suggest that the inhibitory effect of SM-20550 on the neutrophil accumulation could be one of the mechanisms by which this drug limits the severity of infarctions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:14:53