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Titolo:
Molecular heterogeneity of central synapses: afferent and target regulation
Autore:
Craig, AM; Boudin, H;
Indirizzi:
Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 6, volume: 4, anno: 2001,
pagine: 569 - 578
SICI:
1097-6256(200106)4:6<569:MHOCSA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED HIPPOCAMPAL-NEURONS; METABOTROPIC GLUTAMATE-RECEPTOR; CEREBELLAR GRANULE CELLS; LONG-TERM DEPRESSION; DEPENDENT PROTEIN-KINASE; AMPA RECEPTORS; NMDA RECEPTOR; TRANSMITTER RELEASE; GABAERGIC SYNAPSES; SYNAPTIC TRANSMISSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Craig, AM Washington Univ, Sch Med, Dept Anat & Neurobiol, 660 S Euclid,Campus Box 8108,958 McDonnell Sci Bl, St Louis, MO 63110 USA Washington Univ 660 S Euclid,Campus Box 8108,958 McDonnell Sci Bl St Louis MO USA 63110
Citazione:
A.M. Craig e H. Boudin, "Molecular heterogeneity of central synapses: afferent and target regulation", NAT NEUROSC, 4(6), 2001, pp. 569-578

Abstract

Electrophysiological recordings show a functional spectrum even within a single class of synapse, with individual synapses ranging widely in fundamental properties, including release probability, unitary response and effectsof previous stimulation on subsequent response. Molecular and cellular biological approaches have shown a corresponding diversity in the complement of ion channels, receptors, scaffolds and signal transducing proteins that make up individual synapses. Indeed, we believe that each individual synapseis unique, a function of presynaptic cell type, postsynaptic cell type, environment, developmental stage and history of activity. We review here the molecular diversity of glutamatergic and GABAergic synapses in the mammalian brain in the context of potential cell biological mechanisms that may explain how individual cells develop and maintain such a mosaic of synaptic connections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:54:41