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Titolo:
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
Autore:
Makowski, L; Boord, JB; Maeda, K; Babaev, VR; Uysal, KT; Morgan, MA; Parker, RA; Suttles, J; Fazio, S; Hotamisligil, GS; Linton, MF;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 Dept Med, Nashville, TN 37240 USA Harvard Univ, Sch Publ Hlth, Div Biol Sci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Div Biol Sci, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Pathol, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA Bristol Myers Squibb PRI, Dept Metab Res, Princeton, NJ USA Bristol Myers Squibb PRI Princeton NJ USA t Metab Res, Princeton, NJ USA Univ Louisville, Sch Med, Dept Microbiol & Immunol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Immunol, Louisville, KY 40292 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 6, volume: 7, anno: 2001,
pagine: 699 - 705
SICI:
1078-8956(200106)7:6<699:LOMFPA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; BONE-MARROW TRANSPLANTATION; ACTIVATED RECEPTOR-GAMMA; FOAM CELL-FORMATION; PPAR-GAMMA; INSULIN-RESISTANCE; GENE-EXPRESSION; CHOLESTEROL ACYLTRANSFERASE; HUMAN MONOCYTES; OXIDIZED LDL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Linton, MF Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 Nashville, TN 37240 USA
Citazione:
L. Makowski et al., "Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis", NAT MED, 7(6), 2001, pp. 699-705

Abstract

The adipocyte fatty-acid-binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate that aP2 is also expressed in macrophages, has a significant role in their biological responses and contributes to the development of atherosclerosis. Apolipoprotein E (ApoE)-deficient mice also deficient for aP2 showed protection from atherosclerosis in the absence of significant differences inserum lipids or insulin sensitivity. aP2-deficient macrophages showed alterations in inflammatory cytokine production and a reduced ability to accumulate cholesterol esters when exposed to modified lipoproteins. Apoe(-/-) mice with Ap2(+/+) adipocytes and Ap2(-/-) macrophages generated by bone-marrow transplantation showed a comparable reduction in atherosclerotic lesionsto those with total aP2 deficiency, indicating an independent role for macrophage aP2 in atherogenesis. Through its distinct actions in adipocytes and macrophages, aP2 provides a link between features of the metabolic syndrome and could be a new therapeutic target for the prevention of atherosclerosis.

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Documento generato il 22/09/20 alle ore 07:06:15