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Titolo:
Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation
Autore:
Bi, K; Tanaka, Y; Coudronniere, N; Sugie, K; Hong, SJ; van Stipdonk, MJB; Altman, A;
Indirizzi:
La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA LaJolla Inst Allergy & Immunol San Diego CA USA 92121 iego, CA 92121 USA La Jolla Inst Allergy & Immunol, Div Immunochem, San Diego, CA 92121 USA La Jolla Inst Allergy & Immunol San Diego CA USA 92121 iego, CA 92121 USA La Jolla Inst Allergy & Immunol, Div Immune Regulat, San Diego, CA 92121 USA La Jolla Inst Allergy & Immunol San Diego CA USA 92121 iego, CA 92121 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 6, volume: 2, anno: 2001,
pagine: 556 - 563
SICI:
1529-2908(200106)2:6<556:ATOPTM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; KAPPA-B ACTIVATION; LIPID RAFTS; IL-2 PROMOTER; TYROSINE PHOSPHORYLATION; CHOLESTEROL DEPLETION; SIGNAL-TRANSDUCTION; RECEPTOR; TCR; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Altman, A La Jolla Inst Allergy & Immunol, Div Cell Biol, 10355 Sci Ctr Dr, San Diego, CA 92121 USA La Jolla Inst Allergy & Immunol 10355 Sci Ctr Dr San Diego CA USA 92121
Citazione:
K. Bi et al., "Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation", NAT IMMUNOL, 2(6), 2001, pp. 556-563

Abstract

Protein kinase C-theta (PKC-theta) is essential for mature T cell activation; however, the mechanism by which it is recruited to the TCR signaling machinery is unknown. Here we show that T cell stimulation by antibodies or peptide-major histocompatibility complex (MHC) induces translocation of PKC-Q to membrane lipid rafts, which localize to the immunological synapse. Raft translocation was mediated by the PKC-theta regulatory domain and required Lck but not ZAP-70. In addition, PKC-theta was associated with Lck in therafts,An isolated PKC-theta catalytic fragment did not partition into rafts or activate the transcription factor NF-kappaB, although addition of a Lck-derived raft-localization sequence restored these functions. Thus, physiological T cell activation translocates PKC-theta to rafts, which localize to the T cell synapse; this PKC-theta translocation is important for its function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:22:36