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Titolo:
Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines
Autore:
Cinamon, G; Shinder, V; Alon, R;
Indirizzi:
Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 6, volume: 2, anno: 2001,
pagine: 515 - 522
SICI:
1529-2908(200106)2:6<515:SFPLMA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE-1; MEMORY T-CELLS; TRANSENDOTHELIAL MIGRATION; NEUTROPHIL MIGRATION; ADHERENS JUNCTIONS; FLOW CONDITIONS; ACTIVATION; INTEGRIN; ARREST; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Alon, R Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel WeizmannInst Sci Rehovot Israel IL-76100 -76100 Rehovot, Israel
Citazione:
G. Cinamon et al., "Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines", NAT IMMUNOL, 2(6), 2001, pp. 515-522

Abstract

Leukocyte transendothelial migration (TEM) is thought to be a chemotactic process controlled by chemokine gradients across the endothelium. Using cytokine-activated human umbilical vascular endothelial cells (HUVECs) as a model of inflamed endothelium, we have shown that apical endothelial chemokines can trigger robust peripheral blood lymphocyte (PBL) migration across endothelial cells, Lymphocyte TEM was promoted by physiological shear stress applied continuously to migrating lymphocytes. Lymphocyte integrins, intactactin cytoskeleton and G(i) protein-mediated chemokine signaling, but not a chemotactic gradient, were mandatory for TEM, PBL TEM did not require intracellular free calcium or intact phosphatidyl inositol kinase activity in migrating lymphocytes. Thus, lymphocyte TEM is promoted by fluid shear-induced mechanical signals coupled to G(i) protein signals at apical endothelial zones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:26:38