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Titolo:
No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol
Autore:
Mengs, U; Schuler, D; Marshall, RR;
Indirizzi:
Madaus AG, D-51109 Cologne, Germany Madaus AG Cologne Germany D-51109Madaus AG, D-51109 Cologne, Germany Covance Labs Ltd, Harrogate HG3 1PY, England Covance Labs Ltd Harrogate England HG3 1PY d, Harrogate HG3 1PY, England
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 492, anno: 2001,
pagine: 69 - 72
SICI:
1383-5718(20010531)492:1-2<69:NIOCAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE MICRONUCLEUS ASSAY; GENOTOXICITY; CARCINOGENICITY; ANTHRAQUINONES; CHRYSAZIN; EMODIN; SENNA; RAT;
Keywords:
chrysophanol; anthraquinone; genotoxicity; chromosomal aberration; in vitro;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Mengs, U Madaus AG, Ostmerheimer Str 198, D-51109 Cologne, Germany Madaus AG Ostmerheimer Str 198 Cologne Germany D-51109 , Germany
Citazione:
U. Mengs et al., "No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol", MUT RES-GTE, 492(1-2), 2001, pp. 69-72

Abstract

Chrysophanol is an anthraquinone which occurs in several herbal drugs, e.g. senna, a commonly used laxative. As there are only limited data on its clastogenic potential we have investigated its capability to cause chromosomal aberrations in the Chinese hamster ovary cell assay. There were no significant increases in chromosomal aberrations when chrysophanol was rested up to its limit of solubility with or without metabolic activation. We conclude that chrysophanol had no clastogenic activity under the conditions described. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:09:32