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Titolo:
The tau A0 allele in Parkinson's disease
Autore:
Golbe, LI; Lazzarini, AM; Spychala, JR; Johnson, WG; Stenroos, ES; Mark, MH; Sage, JI;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08901 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08901 swick, NJ 08901 USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 3, volume: 16, anno: 2001,
pagine: 442 - 447
SICI:
0885-3185(200105)16:3<442:TTAAIP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; ALPHA-SYNUCLEIN; LEWY BODIES; GENE; PHOSPHORYLATION; PROTEIN; ASSOCIATION; DIAGNOSIS;
Keywords:
Parkinson's disease; tau; genetics; progressive supranuclear palsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Golbe, LI Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, 97 Paterson St, New Brunswick, NJ 08901 USA Univ Med & Dent New Jersey 97 Paterson St New Brunswick NJ USA 08901
Citazione:
L.I. Golbe et al., "The tau A0 allele in Parkinson's disease", MOVEMENT D, 16(3), 2001, pp. 442-447

Abstract

Parkinson's disease (PD) is primarily an alpha -synucleinopathy, rather than a tauopathy, bur there is evidence fur an indirect association of tau with the pathogenetic process in PD. We therefore assessed the frequency in PD of the tau A0 allele, a dinucleotide repeat marker that has been associated with a sporadic tauopathy, progressive supranuclear palsy (PSP). We found the A0 allele to comprise 79.2% of 758 alleles from PD patients and 71.2%of 264 control alleles (P = 0.008). We also performed a meta-analysis of three previous reports, two of which failed to produce statistically significant results. Taken together, they also support a PD/A0 allelic association, even after correction for misdiagnosis of PSP as PD (P< 0.001). The A0/A0genotype frequency in our patients (62.3%) did not differ significantly from that in controls (53.0%, P = 0.062), but the mete-analysis, even after correction for misdiagnosis, showed a significant result, with P = 0.002. The frequency of A0 allele and the A0/A0 genotype were compatible with Hardy-Weinberg equilibrium. The frequency of the A0 allele and the A0/A0 genotypein our patients with familial PD was not significantly greater than in those with sporadic PD. We conclude that the tau protein map play a small rolein the pathogenesis of PD and that biochemical characterization of this role may suggest opportunities for PD prophylaxis. (C) 2001 Movement Disordersociety.

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Documento generato il 23/01/20 alle ore 13:15:59