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Titolo:
Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease
Autore:
Muriel, MP; Agid, Y; Hirsch, E;
Indirizzi:
Hop La Pitie Salpetriere, INSERM, U289, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 289, F-75013 Paris, France
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 3, volume: 16, anno: 2001,
pagine: 435 - 441
SICI:
0885-3185(200105)16:3<435:POAFTS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEVODOPA-INDUCED DYSKINESIAS; MOTOR RESPONSE ALTERATIONS; BASAL GANGLIA; MORPHOLOGICAL-CHANGES; HALOPERIDOL TREATMENT; SYNAPTIC PLASTICITY; GLUTAMATE SYNAPSES; SUBSTANTIA-NIGRA; RAT NEOSTRIATUM; D-1 RECEPTOR;
Keywords:
basal ganglia; plasticity; dopamine receptor; Parkinson;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hirsch, E Hop La Pitie Salpetriere, INSERM, U289, 47 Blvd Hop, F-75013 Paris, France Hop La Pitie Salpetriere 47 Blvd Hop Paris France F-75013 rance
Citazione:
M.P. Muriel et al., "Plasticity of afferent fibers to striatal neurons bearing D1 dopamine receptors in Parkinson's disease", MOVEMENT D, 16(3), 2001, pp. 435-441

Abstract

The loss of dopaminergic neurons in the substantia nigra provokes a plasticity of corticostriatal synapses in Parkinson's disease (PD). The corticostriatal pathway nevertheless makes synapses with neurons bearing D1 dopaminereceptors (D1R) and/or D2 dopamine receptors. At the ultrastructural level, we analyzed the morphological characteristics of synapses formed by afferent fibers making asymmetric contacts with the dendritic spines of neurons identified by D1R immunoreactivity, in the striatum of control subjects andPD patients. A quantitative analysis of the morphological characteristics of the synapses and of the number of perforated synapses (considered to be very active) was performed. In PD, a 50% increase in the number of perforated synapses making contact with DIR dendritic spines was observed, whereas no change in the number of perforated synapses on non-D1R spines was observed. The change in the number of perforated synapses on DIR dendrites was associated with a slight but nonsignificant increase in the surface area of the corticostriatal afferent fibers and the surface of the mitochondria in these fibers (+29.0% and +34.6%, respectively). This suggests a hyperactivity of corticostriatal fibers in contact with DIR-bearing neurons of the direct pathway in the basal ganglia circuitry. Since stimulation of the direct pathway is thought to alleviate the clinical symptoms of PD, this suggests that the differences observed may be involved in compensatory mechanisms. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:39:55