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Titolo:
Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, inrats with partial 6-OHDA or FeCl3 nigrostriatal lesions
Autore:
Datla, KP; Blunt, SB; Dexter, DT;
Indirizzi:
Imperial Coll Sch Med, Dept Neuroinflammat, Parkinsons Dis Res Unit, London W6 8RF, England Imperial Coll Sch Med London England W6 8RF Unit, London W6 8RF, England
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 3, volume: 16, anno: 2001,
pagine: 424 - 434
SICI:
0885-3185(200105)16:3<424:CLAINT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; NEUROTROPHIC FACTOR; SUBSTANTIA-NIGRA; 6-HYDROXYDOPAMINE LESION; MESENCEPHALIC CULTURES; MIDBRAIN NEURONS; MOUSE-BRAIN; LEVODOPA; CARBIDOPA; NEUROTOXICITY;
Keywords:
Parkinson's disease; L-DOPA; neuroprotection; oxidative stress; neurodegeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Dexter, DT Imperial Coll Sch Med, Dept Neuroinflammat, Parkinsons Dis Res Unit, Charing Cross Campus,Fulham Palace Rd, London W6 8RF, England Imperial Coll Sch Med Charing Cross Campus,Fulham Palace Rd London England W6 8RF
Citazione:
K.P. Datla et al., "Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, inrats with partial 6-OHDA or FeCl3 nigrostriatal lesions", MOVEMENT D, 16(3), 2001, pp. 424-434

Abstract

In this study, we have examined the effects of chronic L-3,4-dihydroxyphenylalanine (L-DOPA) administration on the remaining dopaminergic neurons in rats with 6-hydroxydopamine (6-OHDA) or buffered FeCl3 partial lesions to the nigrostriatal tract. L-DOPA administration increased the turnover of dopamine in the striatum. L-DOPA administration for 1 week produced an increase in the level of striatal RTI-121 binding, a specific marker for dopamine uptake sites: on the dopaminergic nerve terminals in the striatum. However,longer periods of L-DOPA treatment decreased the level of RTI-121 binding in the striatum. In the partial 6-OHDA lesion model, L-DOPA treatment had atime-dependent effect on the number of neurons demonstrating a dopaminergic phenotype i.e., neurons that are tyrosine hyrdoxylase (TH)immunopositive,on the lesioned side of the brain. In the first few weeks of treatment, L-DOPA decreased the number of TH-positive neurons but with long-term treatment, i.e., 24 weeks, L-DOPA increased the number of neurons demonstrating a dopaminergic phenotype, Even in the buffered FeCl3 infusion model, where the levels of iron were increased, L-DOPA treatment did not have any detrimental effects on the number of TH-positive neurons on the lesioned side of the brain. Consequently, chronic L-DOPA treatment does not have any detrimental effects to the remaining dopaminergic neurons in rats with partial lesions to the nigrostriatal tract, indeed in the 6-OHDA lesion model, long-termL-DOPA may increase the number of neurons, demonstrating a dopaminergic phenotype. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:19:09