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Titolo:
Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor
Autore:
Shimuta, M; Yoshikawa, M; Fukaya, M; Watanabe, M; Takeshima, H; Manabe, T;
Indirizzi:
Kobe Univ, Sch Med, Dept Physiol, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 pt Physiol, Kobe, Hyogo 6500017, Japan Univ Tokyo, Fac Med, Dept Neurophysiol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 , Dept Neurophysiol, Tokyo 1130033, Japan Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Kurume Univ, Inst Life Sci, Div Cell Biol, Kurume, Fukuoka 8390861, Japan Kurume Univ Kurume Fukuoka Japan 8390861 , Kurume, Fukuoka 8390861, Japan Univ Tokyo, Div Neuronal Network, Dept Basic Med Sci, Inst Med Sci, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 d Sci, Inst Med Sci, Tokyo 1088639, Japan
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 5, volume: 17, anno: 2001,
pagine: 921 - 930
SICI:
1044-7431(200105)17:5<921:PMOARS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; MUTANT MICE LACKING; METABOTROPIC GLUTAMATE RECEPTORS; CA2+ RELEASE CHANNELS; PROTEIN-KINASE-II; GYRUS IN-VITRO; HIPPOCAMPAL-NEURONS; SKELETAL-MUSCLE; NMDA RECEPTORS; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Manabe, T Kobe Univ, Sch Med, Dept Physiol, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 , Kobe, Hyogo 6500017, Japan
Citazione:
M. Shimuta et al., "Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor", MOL CELL NE, 17(5), 2001, pp. 921-930

Abstract

The precise function of ryanodine receptors (RyRs) in synaptic transmission is unknown, but three of their subtypes are expressed in the brain. We examined the role of RyRs in excitatory synaptic transmission in hippocampal slices, using type 3 RyR (RyR3)-deficient mice. The alpha -amino-3-hydroxy-5-methyl-4-isoxo-zolepropionic acid (AMPA) receptor-mediated basal synapticresponses in the CA1 region of mutant mice were smaller than those of wild-type mice, while there was no difference in N-methyl-D-aspartate receptor-mediated responses, suggesting selective postsynaptic modification of AMPA receptors by RyR3. The expression of synaptic AMPA receptor subunits examined by Western blotting or immunohistochemistry was indistinguishable, suggesting that the smaller AMPA synaptic responses in mutant mice were not due to the reduced number of synaptic AMPA receptors. Although the initial potentiation following tetanic stimulation of afferent fibers was similar, long-term potentiation (LTP) was smaller in mutant mice. There were no differences in presynaptic electrophysiological properties. We thus conclude that RyR3 postsynaptically regulates the properties of AMPA receptors and LTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:50:52