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Titolo:
Spatially restricted expression of regulators of G-protein signaling in primary olfactory neurons
Autore:
Norlin, EM; Berghard, A;
Indirizzi:
Umea Univ, Dept Cell & Mol Biol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Dept Cell & Mol Biol, S-90187 Umea, Sweden
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 5, volume: 17, anno: 2001,
pagine: 872 - 882
SICI:
1044-7431(200105)17:5<872:SREORO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PHEROMONE RECEPTORS; GTPASE-ACTIVATING PROTEINS; ADENYLYL-CYCLASE; ODORANT RECEPTOR; VOMERONASAL ORGAN; ACCELERATING PROTEIN; MULTIGENE FAMILY; FUNCTIONAL EXPRESSION; PHOSPHOLIPASE-C; ALPHA-SUBUNITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Berghard, A Umea Univ, Dept Cell & Mol Biol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Mol Biol, S-90187 Umea, Sweden
Citazione:
E.M. Norlin e A. Berghard, "Spatially restricted expression of regulators of G-protein signaling in primary olfactory neurons", MOL CELL NE, 17(5), 2001, pp. 872-882

Abstract

The intracellular signal transduction machinery of heterotrimeric G-protein coupled odorant and putative pheromone receptors converts odorous information into a cellular response. We have investigated for the presence of 18 members of the family termed "regulators of G-protein signaling" (RGS) in primary olfactory sensory neurons of the main as well as the accessory (vomeronasal) system of the mouse. Unexpectedly, expression of a few nos membersshow spatial restrictions correlating with the patterns described for G-protein coupled receptors in these two types of olfactory neurons. RGS3 was selectively coexpressed with the G alpha i2 G-protein subunit in a subpopulation of vomeronasal neurons. The mutually exclusive spatial extents of RGS9and RGSZ1 expression in main olfactory neurons corresponded precisely to that of certain odorant receptor zones. This renders these RGS members the first described intracellular signal transduction components with a potential role in the spatially organized sensory coding in the main olfactory system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:51:16