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Titolo:
Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism
Autore:
Woo, D; Lee, GY; Anderson, E; Aziz, N;
Indirizzi:
Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA Univ Calif LosAngeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Childrens Hosp, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Childrens Hosp, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 176, anno: 2001,
pagine: 155 - 162
SICI:
0303-7207(20010515)176:1-2<155:IOAPKI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; RAT UTERUS; CPK MOUSE; DISEASE; KE-6; DEHYDROGENASE; PROGESTERONE; INDUCTION; APOPTOSIS; ESTROGEN;
Keywords:
hydroxysteroid dehydrogenase; polycystic; cpk/cpk mouse; Ke 6; development; gonada;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Aziz, N Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 les, CA 90095 USA
Citazione:
D. Woo et al., "Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism", MOL C ENDOC, 176(1-2), 2001, pp. 155-162

Abstract

Ke 6 is a 17 beta -hydroxysteroid dehydrogenase (17 beta HSD) that is expressed in the kidneys and gonads. The expression of this gene is markedly reduced in three murine models of recessive polycystic kidney disease, a developmental disorder, where some nephrons within the affected kidneys developinto huge fluid-filled cysts while the non-cystic nephrons atrophies by apoptosis. Here, we show that in the cpk/cpk mouse, which have polycystic kidneys, the female reproductive organs also fail to mature properly and remain arrested at an early stage of development. Direct measurement of 17 beta HSD activity showed a severe reduction in estrogen and androgen metabolism within gonadal and non-gonadal tissues of the cpk/cpk mouse. Using immunofluorescent staining we localized the expression of the Ke 6 protein within the female mouse reproductive organs. Our findings suggest that estrogen/androgen metabolism may play an important role in the development of the urogenital systems. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:58:22