Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis
Autore:
McDougall, K; Kubu, C; Verdi, JM; Meakin, SO;
Indirizzi:
John P Robarts Res Inst, Neurodegenerat Grp, London, ON N6A 5K8, Canada John P Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada John P Robarts Res Inst, Lab Stem Cell Biol, London, ON N6A 5K8, Canada John P Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada John P Robarts Res Inst, Lab Neural Signaling, London, ON N6A 5K8, Canada John P Robarts Res Inst London ON Canada N6A 5K8 ndon, ON N6A 5K8, Canada Univ Western Ontario, Dept Physiol, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada Univ Western Ontario, Dept Biochem, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada Univ Western Ontario, Grad Program Neurosci, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 103, anno: 2001,
pagine: 145 - 148
SICI:
0925-4773(200105)103:1-2<145:DEPOTS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; SYMPATHETIC NEURONS; CEREBRAL-CORTEX; NERVOUS-SYSTEM; MICE; RECEPTORS; SNT; PROTEINS; DIFFERENTIATION; PROLIFERATION;
Keywords:
FRS2; FRS3; SNT1; SNT2; FRS2 alpha; FRS2 beta; neural tube; nerve growth factor; fibroblast growth factor; Trk receptors; neurotrophins; gene expression; signaling adaptor protein; mouse; embryogenesis; embryo; patterning; RNA; in situ; PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Meakin, SO John P Robarts Res Inst, Neurodegenerat Grp, 100 Perth Dr, London, ON N6A 5K8, Canada John P Robarts Res Inst 100 Perth Dr London ON Canada N6A 5K8 a
Citazione:
K. McDougall et al., "Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis", MECH DEVEL, 103(1-2), 2001, pp. 145-148

Abstract

Two fibroblast growth factor (FGF) receptor substrates (FRS2 and FRS3) areinvolved in downstream signaling from activated FGF receptors and neurotrophin-activated Trk receptors. Despite the importance of signaling from these factors in embryogenesis, FRS2 and FRS3 expression patterns during development are unknown. In this study we characterize the expression of FRS3 andFRS3 from E7 to parturition and in adult murine tissues. Both are first detected in whole E8.5 CD1 mouse embryos. FRS2 is detected as early as E7 in the developing syncytiotrophoblast, later in the neural tube (NT) and in many adult and fetal tissues. FRS3 is more restricted in location than FRS2 (fetal NT, heart, stomach, liver and some adult tissues), and is expressed predominantly in the ventricular layer of the developing NT and brains of murine embryos. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 23:14:18