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Titolo:
Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
Autore:
Kammermeier, L; Leemans, R; Hirth, F; Flister, S; Wenger, U; Walldorf, U; Gehring, WJ; Reichert, H;
Indirizzi:
Univ Basel, Bioctr, Pharmactr, Inst Zool, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 st Zool, CH-4056 Basel, Switzerland Univ Basel, Bioctr, Pharmactr, Dept Cell Biol, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 ll Biol, CH-4056 Basel, Switzerland Univ Hohenheim, Inst Genet, D-70593 Stuttgart, Germany Univ Hohenheim Stuttgart Germany D-70593 net, D-70593 Stuttgart, Germany
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 103, anno: 2001,
pagine: 71 - 78
SICI:
0925-4773(200105)103:1-2<71:DEAFOT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEOBOX-CONTAINING GENE; EMPTY SPIRACLES; CELL-DIFFERENTIATION; BOUNDARY FORMATION; MUSHROOM BODIES; EYE; BRAIN; ANIRIDIA; INTERFERENCE; DACHSHUND;
Keywords:
Drosophila; central nervous system development; Pax genes; eyeless; twin of eyeless; brain development; embryo; neurogenesis; immunocytochemistry; mutants; RNA interference; misexpression; confocal microscopy; evolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Reichert, H Univ Basel, Bioctr, Pharmactr, Inst Zool, Klingelbergstr 50, CH-4056 Basel, Switzerland Univ Basel Klingelbergstr 50 Basel Switzerland CH-4056 erland
Citazione:
L. Kammermeier et al., "Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development", MECH DEVEL, 103(1-2), 2001, pp. 71-78

Abstract

We analyzed the expression and function of eyeless (ey) and twin of eyeless (toy) in the embryonic central nervous system (CNS) of Drosophila. Both genes are differentially expressed in specific neuronal subsets (but not in glia) in every CNS neuromere, and in the brain, specific cell populations co-expressing both proteins define a longitudinal domain which is intercalated between broad exclusive expression domains of ey and toy. Studies of genetic null alleles and dsRNA interference did not reveal any gross neuroanatomical effects of rv, ro?, or ey/toy elimination in the embryonic CNS. In contrast, targeted misexpression of ey, but not of toy, resulted in profoundaxonal abnormalities in the embryonic ventral nerve cord and brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:48:52