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Titolo:
Determination of oral dosage and pharmacokinetic analysis of flecainide inhorses
Autore:
Ohmura, H; Hiraga, A; Aida, H; Takahashi, T; Nukada, T;
Indirizzi:
Japan Racing Assoc, Equine Sci Div, Hidaka Yearling Training Farm, Urakawa, Hokkaido 0570171, Japan Japan Racing Assoc Urakawa Hokkaido Japan 0570171 Hokkaido 0570171, Japan JRA, Equine Res Inst, Utsunomiya, Tochigi 3200856, Japan JRA Utsunomiya Tochigi Japan 3200856 , Utsunomiya, Tochigi 3200856, Japan JRA, Joban Branch, Equine Res Inst, Iwaki, Fukushima 9728325, Japan JRA Iwaki Fukushima Japan 9728325 s Inst, Iwaki, Fukushima 9728325, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 5, volume: 63, anno: 2001,
pagine: 511 - 514
SICI:
0916-7250(200105)63:5<511:DOODAP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAROXYSMAL ATRIAL-FIBRILLATION; ACUTE CONVERSION; SINUS RHYTHM; ACETATE; FLUTTER;
Keywords:
equine; flecainide; oral administration; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Ohmura, H Japan Racing Assoc, Equine Sci Div, Hidaka Yearling Training Farm, 535-13 Aza Nishicha, Urakawa, Hokkaido 0570171, Japan Japan Racing Assoc535-13 Aza Nishicha Urakawa Hokkaido Japan 0570171
Citazione:
H. Ohmura et al., "Determination of oral dosage and pharmacokinetic analysis of flecainide inhorses", J VET MED S, 63(5), 2001, pp. 511-514

Abstract

TO determine oral dosage and to evaluate the pharmacokinetics in horses oforally administered flecainide, an antiarrhythmic drug, the correlations between its plasma concentration and PR, QRS and QT intervals in equine electrocardiograms (ECG) were investigated. Six healthy horses were administered a randomly ordered dose of 4 or 6 mg/kg of flecainide acetate. The ECG was monitored (heart rate (HR), PR, QRS, and QT intervals) and blood was taken at timed intervals to measure the plasma flecainide concentrations pre- and post-administration The maximum plasma concentration reached 1014 +/- 285 (SD) ng/ml in 45 +/- 13 min and 1301 +/- 400 ng/ mi in 60 +/- 37 min for doses of 4 and 6 mg/kg flecainide, respectively. From the pharmacokinetic analysis, clearance rates were 14.6 +/- 6.4 and 11.7 +/- 5.2 ml/kg/min and terminal elimination half-lives were 228 +/- 53 and 304 +/- 87 min. The QRS and QT intervals increased significantly for both doses following administration, though HR and PR intervals did not change. Plasma flecainide concentrations were significantly correlated with QRS (r=0.935, P <0.001) and QT intervals (r=0.753, P <0.001). In conclusion, plasma concentrations of flecainide for treating equine atrial fibrillation were obtained by oral administration of 4 and 6 mg/kg, and the drug was rapidly eliminated from plasma in horses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:58:43