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Titolo:
mDll1 and mDll3 expression in the developing mouse brain: Role in the establishment of the early cortex
Autore:
Campos, LS; Duarte, AJ; Branco, T; Henrique, D;
Indirizzi:
Lisbon Med Sch, FML, Dev Biol Unit, Lisbon, Portugal Lisbon Med Sch Lisbon Portugal ch, FML, Dev Biol Unit, Lisbon, Portugal
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 6, volume: 64, anno: 2001,
pagine: 590 - 598
SICI:
0360-4012(20010615)64:6<590:MAMEIT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; STEM-CELLS; NEURONAL MIGRATION; PROGENITOR CELLS; CEREBRAL-CORTEX; XENOPUS EMBRYOS; DELTA-HOMOLOG; NOTCH LIGAND; GLIAL-CELLS; NEUROGENESIS;
Keywords:
neurogenesis; cortex; development; mDll1; mDll3; telencephalon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Campos, LS CCBR, Forvie Site,Robinson Way, Cambridge CB2 2PY, England CCBRForvie Site,Robinson Way Cambridge England CB2 2PY ngland
Citazione:
L.S. Campos et al., "mDll1 and mDll3 expression in the developing mouse brain: Role in the establishment of the early cortex", J NEUROSC R, 64(6), 2001, pp. 590-598

Abstract

The Delta/Notch signalling system is involved in several developmental processes. During fly neurogenesis, Delta expression defines the fate of neuronal precursors and inhibits neighboring Notch-expressing cells from acquiring a neural fate, a process known as lateral inhibition. In vertebrates, recent evidence demonstrates that Notch activation can positively determine cell fate and affect neuronal process extension. Nevertheless, Delta-like expression patterns during brain development are relatively unknown. Using a transgenic mouse, which expresses LacZ under the mDII1 promoter, we show byimmunofluorescence that in the developing telencephalon mDII1 is expressedin undifferentiated cells in close contact with radial glial cells. Based on in situ hybridization data on mDII1 and mDII3 mRNA expression and on theimmunohistochemical detection of beta -galactosidase in the DII1-lacZ transgenic mouse, we suggest that mDII1 and mDII3 are involved in the establishment of the early cortical plate and that mDII1-expressing cells are in close contact with radial glial cells, thereby modulating the latter population, which is known to express Notch1, Furthermore, we suggest that the decrease in mDII1 mRNA found toward the end of gestation could be related, first, to the slowing of neurogenesis and, second, to the differentiation of theradial glial cell population into astrocytes. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:05:17