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Titolo:
An apparatus and behavioral training protocol to conduct positron emissiontomography (PET) neuroimaging in conscious rhesus monkeys
Autore:
Howell, LL; Hoffman, JM; Votaw, JR; Landrum, AM; Jordan, JF;
Indirizzi:
Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 eg Primate Res Ctr, Atlanta, GA 30322 USA Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ, Dept Pharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 iv, Dept Pharmacol, Atlanta, GA 30322 USA Emory Univ, Dept Radiol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Univ, Dept Radiol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 2, volume: 106, anno: 2001,
pagine: 161 - 169
SICI:
0165-0270(20010430)106:2<161:AAABTP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; AUTOMATED IMAGE REGISTRATION; INTRAVENOUS (H2O)-O-15; POLYDRUG USERS; ERROR ANALYSIS; COCAINE ABUSE; BRAIN; VALIDATION; TECHNETIUM-99M-HMPAO; PERFUSION;
Keywords:
positron emission tomography (PET); cocaine; cerebral blood flow; nonhuman primates; neuroimaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Howell, LL Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Res Ctr, Atlanta, GA 30322 USA
Citazione:
L.L. Howell et al., "An apparatus and behavioral training protocol to conduct positron emissiontomography (PET) neuroimaging in conscious rhesus monkeys", J NEUROSC M, 106(2), 2001, pp. 161-169

Abstract

Nonhuman primates offer a unique resource in neuroimaging research, providing the opportunity to manipulate appropriate biological and behavioral variables under well-controlled experimental conditions in an animal model that is closely related to humans, both functionally and neuroanatomically. The present report describes the development and standardization of PET neuroimaging protocols in conscious rhesus monkeys and their application to characterize the acute effects of cocaine on cerebral blood flow. Specific attention was devoted to the development of an effective and comfortable head restraint device to be used in the imaging of conscious monkeys. The restraint device was designed to attach to a standard primate chair to facilitate frequent immobilization. Subjects received extensive behavioral training prior to neuroimaging in order to ensure their comfort and minimize potentialstress associated with the imaging protocols. Functional changes in cerebral blood flow were characterized in three subjects with the positron-emitting tracer O-15 water following acute i.v. administration of cocaine. Regions of interest were defined on MRI scans with a high degree of accuracy. Cocaine caused pronounced increases in cerebral blood flow at 5 min postinjection that diminished markedly within 25 min. The results document the feasibility to conduct PET neuroimaging studies of cerebral blood flow in conscious nonhuman primates. Extension of the methodology to include brain activation during behavioral studies could contribute significantly to the growingdiscipline of behavioral neuroscience. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:10:46