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Titolo:
Characterisation of a South African human astrovirus as type 8 by antigenic and genetic analyses
Autore:
Taylor, MB; Walter, J; Berke, T; Cubitt, WD; Mitchell, DK; Matson, DO;
Indirizzi:
Univ Pretoria, Dept Med Virol, Inst Pathol, ZA-0001 Pretoria, South AfricaUniv Pretoria Pretoria South Africa ZA-0001 -0001 Pretoria, South Africa Eastern Virginia Med Sch, Childrens Hosp Kings Daughters, Ctr Pediat Res, Norfolk, VA 23501 USA Eastern Virginia Med Sch Norfolk VA USA 23501 Res, Norfolk, VA 23501 USA Great Ormond St Hosp Children, Camelia Botnar Labs, Dept Virol, London WC1N 3JH, England Great Ormond St Hosp Children London England WC1N 3JH WC1N 3JH, England
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 3, volume: 64, anno: 2001,
pagine: 256 - 261
SICI:
0146-6615(200107)64:3<256:COASAH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR CHARACTERIZATION; ACUTE GASTROENTERITIS; ELECTRON-MICROSCOPY; ENZYME-IMMUNOASSAY; SEROTYPES; CHILDREN; EPIDEMIOLOGY; INFECTION; SEQUENCE; REGION;
Keywords:
astrovirus type 8; RT-PCR; serotype; genotype; homology; phylogeny;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, MB Univ Pretoria, Dept Med Virol, Inst Pathol, POB 2034, ZA-0001 Pretoria, South Africa Univ Pretoria POB 2034 Pretoria South Africa ZA-0001th Africa
Citazione:
M.B. Taylor et al., "Characterisation of a South African human astrovirus as type 8 by antigenic and genetic analyses", J MED VIROL, 64(3), 2001, pp. 256-261

Abstract

Human astroviruses (HAstV) can, on the basis of immunoassays using type-specific rabbit antisera, be classified into eight serotypes that correlate with genotypes. Very few isolates of HAstV type 8 have been described and there is a paucity of data available with regard to the antigenic and geneticrelationships between HAstV type 8 (HAstV-8) and HAstV types 1 (HAstV-1) to 7 (HAstV-7). A wild-type HAstV from a South African paediatric patient with diarrhoea was analysed antigenically, by immune electron microscopy and enzyme immunoassay, and genetically in selected regions of the ORF1a, ORF1band ORF2 and characterised as a HAstV-8. This HAstV-8 strain exhibited greatest homology with HAstV-4 in the 5 ' end of the capsid gene and ORF1a andIb, and greatest homology with HAstV-5 in the 3 ' end of the capsid region. This study confirms, by both antigenic and genetic analyses, that HAstV-8represents a distinct antigenic and genotype and is the first report of a HAstV-8 from a hospitalised paediatric patient with diarrhoea in southern Africa. J. Mad. Virol. 64:256-261, 2001. (C) 2001 Wiley-liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:08:29