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Titolo:
Monitoring the response to antiretroviral therapy in HIV-1 group O infected patients using two new RT-PCR assays
Autore:
de Mendoza, C; Lu, W; Machuca, A; Sainz, M; Castilla, J; Soriano, V;
Indirizzi:
Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain Hosp Carlos III Madrid Spain Carlos III, Infect Dis Serv, Madrid, Spain Univ Paris 05, Hop Laennec, Fac Med, Mol Biol & Oncol Lab, F-75270 Paris 06, France Univ Paris 05 Paris France 06 Biol & Oncol Lab, F-75270 Paris 06, France Abbott Diagnost, Dept Med, Madrid, Spain Abbott Diagnost Madrid SpainAbbott Diagnost, Dept Med, Madrid, Spain Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid, Spain Inst Salud CarlosIII Madrid Spain I, Ctr Nacl Epidemiol, Madrid, Spain
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 3, volume: 64, anno: 2001,
pagine: 217 - 222
SICI:
0146-6615(200107)64:3<217:MTRTAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; VIRAL-RNA QUANTITATION; PLASMA; SUBTYPES; STRAINS; VIRION; LOAD;
Keywords:
HIV-1 group O; viral load; quantitative assay; antiretroviral therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
C. de Mendoza et al., "Monitoring the response to antiretroviral therapy in HIV-1 group O infected patients using two new RT-PCR assays", J MED VIROL, 64(3), 2001, pp. 217-222

Abstract

Failure to recognise infection caused by human immunodeficiency virus type1 (HIV-1) group O variants has been described using both serological and genetic procedures. Moreover, monitoring the response to antiretroviral therapy is a difficult task in patients infected with HIV-1 group O since commercial tests are not available so far for the quantitation of this virus. inthis study, the virological response to antiretroviral therapy were assessed in five HIV-1 group O-infected patients living in Spain by using two newand different RT-PCR methods (MUPROVAMA and LCx). Twenty-four plasma samples belonging to these five patients were selected. As reference, p24 antigenaemia levels and CD4+ cell counts were used. All samples yielded positive viral load values using MUPROVAMA (range: 138 to 595,500 HIV-RNA copies/ml)and 23 of 24 using LCx (range: < 178 to 98,356 HIV-RNA copies/ml). Overall, the results obtained using both assays showed a good correlation among themselves, and in respect to p24 antigenaemia and CD4+ cell counts. However,the values provided by LCx were significantly lower (0.33 logs on average)than those provided by MUPROVAMA. In conclusion, both the highly sensitiveMUPROVAMA and LCx Quantitative assays might represent an useful tool for guiding the decision on when start treatment and for monitoring the responseto antiretroviral therapy in HIV-1 group O-infected patients. J. Med. Virol. 64:217-222, 2001. (C), 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:26:56