Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thoracoscopy as a nonpharmacotherapeutic research modification for limiting postoperative chest pain
Autore:
Hampshire, VA; Thomas, ML; Bacher, JD; Alling, DW; Kindt, TJ; Wyatt, RG; Simpson, RM;
Indirizzi:
NIAID, Immunogenet Lab, Twinbrook Facil, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 ab, Twinbrook Facil, Rockville, MD 20852 USA NIAID, Off Sci Director, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 D, Off Sci Director, Rockville, MD 20852 USA NIH, Vet Resources Program, Off Res Serv, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 s Program, Off Res Serv, Bethesda, MD 20892 USA NIH, Off Intramural Res, Off Director, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 mural Res, Off Director, Bethesda, MD 20892 USA NIH, Biostat Sect, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF INVESTIGATIVE SURGERY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 109 - 120
SICI:
0894-1939(200103/04)14:2<109:TAANRM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL USE; KETOPROFEN; SURGERY; PHARMACOKINETICS; THORACOTOMY; REFINEMENT; ANESTHESIA; MORBIDITY; ENDOCRINE; HORSES;
Keywords:
animal testing alternatives; disease model in animals; endoscopy; nonsteroidal anti-inflammatory agents (therapeutic and toxic effects); one-lung anesthesia; pain measurement/veterinary; research/procedures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, RM NIAID, Immunogenet Lab, Twinbrook Facil, 12441 Parklawn Dr, Rockville, MD 20852 USA NIAID 12441 Parklawn Dr Rockville MD USA 20852 e, MD 20852 USA
Citazione:
V.A. Hampshire et al., "Thoracoscopy as a nonpharmacotherapeutic research modification for limiting postoperative chest pain", J INVES SUR, 14(2), 2001, pp. 109-120

Abstract

Diminished tissue injury and shortened clinical recovery are benefits of using an endoscopic approach for patients needing operative procedure. In the course of developing an experimental model requiring procurement of topographically precise lung biopsy specimens, we sought to apply thoracoscopy as a research alternative to thoracotomy. In addition, we investigated the influence of thoracoscopy on postprocedure recovery practices using rabbits divided into four treatment groups. Rabbit groups 1 and 2 underwent thoracoscopy and lung biopsy while maintained by one-lung anesthesia. Additionally, group 2 had ketoprofen and bupivacaine HCl analgesics injected for treatment during postprocedure recovery. These two groups were compared to control rabbits in groups 3 and 4, which underwent inhalant anesthesia without thoracoscopy. Control group 3 also received the injection analgesic combination. During recovery, rabbit behavior was systematically assessed for evidence of pain. No behavior considered indicative of pain needing intervention was observed regardless of treatment group. Limited changes in plasma corticosterone, catecholamines, and prostaglandin E-2 levels measured during recovery were difficult to associate with any treatment. Unexpectedly, significantly different mean corticosterone and catecholamines levels were detected in rabbits given the injection analgesic combination in the absence of thoracoscopic procedure, as compared to other treatment groups. The results highlight the importance of awareness that analgesic drug administration hasthe potential to alter homeostasis and affect interpretation of some studyfindings by its own guise. Correlation of the mean pain study results withplasma biochemical data supports preferential use of thoracoscopy as a refinement for limiting postprocedural pain in research models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:52:21