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Titolo:
Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects
Autore:
Narkiewicz, K; Kato, M; Phillips, BG; Pesek, CA; Choe, I; Winnicki, M; Palatini, P; Sivitz, WI; Somers, VK;
Indirizzi:
Mayo Clin, Dept Internal Med, Div Hypertens, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 , Div Hypertens, Rochester, MN 55905 USA Mayo Clin, Dept Internal Med, Div Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 Cardiovasc Dis, Rochester, MN 55905 USA Med Univ Gdansk, Dept Hypertens & Diabetol, Gdansk, Poland Med Univ Gdansk Gdansk Poland Dept Hypertens & Diabetol, Gdansk, Poland Univ Iowa, Div Clin & Adm Pharm, Iowa City, IA USA Univ Iowa Iowa City IAUSA Iowa, Div Clin & Adm Pharm, Iowa City, IA USA Univ Iowa, Dept Internal Med, Iowa City, IA USA Univ Iowa Iowa City IA USA iv Iowa, Dept Internal Med, Iowa City, IA USA Univ Padua, Med Clin 1, Padua, Italy Univ Padua Padua ItalyUniv Padua, Med Clin 1, Padua, Italy
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 6, volume: 19, anno: 2001,
pagine: 1089 - 1094
SICI:
0263-6352(200106)19:6<1089:LIWHRB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; OBESE GENE; BAROREFLEX CONTROL; GENDER DIFFERENCES; PLASMA LEPTIN; HUMANS; MUSCLE; HYPERTENSION; WEIGHT; NORADRENALINE;
Keywords:
leptin; heart rate; hypertension; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Somers, VK Mayo Clin, Dept Internal Med, Div Hypertens, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin 200 1st St SW Rochester MN USA 55905 er, MN 55905 USA
Citazione:
K. Narkiewicz et al., "Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects", J HYPERTENS, 19(6), 2001, pp. 1089-1094

Abstract

Objective Administration of leptin to animals increases sympathetic nerve activity and heart rate. We therefore tested the hypothesis that plasma leptin is linked independently to muscle sympathetic nerve activity (MSNA) andheart rate in healthy humans. Methods We measured plasma leptin, plasma insulin, body mass index (BMI), percent body fat, waist:hip ratio, MSNA, heart rate and blood pressure in 88 healthy individuals (50 men and 38 women). Results In men, plasma leptin concentration correlated significantly with BMI (r= 0.75, P < 0.001), percent body fat (r= 0.70, P< 0.001), waist:hip ratio (r= 0.69, P< 0.001), insulin (r= 0.37, P= 0.009), and age (r= 0.38, P=0.006). Only BMI and waist:hip ratio were linked independently to plasma leptin concentration (r= 0.78, P< 0.001), Plasma leptin concentrations also correlated with heart rate (r= 0.39, P= 0.006) and mean arterial pressure (MAP; r= 0.38, P= 0.007), but not with MSNA (r= 0.17, P= 0.24), After adjustment for BMI and waist:hip ratio, plasma leptin concentration correlated significantly only with heart rate (r= 0.29, P= 0.04), and not with MAP (r= 0,21, P= 0.14). Individuals were divided into high-leptin and low-leptin subgroups on the basis of plasma leptin concentrations adjusted for BMI and waist:hip ratio. Those with high leptin concentrations had significantly faster heart rates than those with low leptin, MAP and MSNA were similar in both subgroups. No relationship between leptin and either heart rate or MSNA was evident in women. Conclusions In normal men, heart rate, but not MSNA, is linked to plasma leptin concentration. This sex-specific relationship between heart rate and plasma leptin is independent of plasma insulin, BMI, waist:hip ratio and percentage body fat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:27:11