Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Combination of endoscopic argon plasma coagulation and antireflux surgery for treatment of Barrett's esophagus
Autore:
Tigges, H; Fuchs, KH; Maroske, J; Fein, M; Freys, SM; Muller, J; Thiede, A;
Indirizzi:
Univ Wurzburg, Dept Surg, Inst Pathol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Pathol, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF GASTROINTESTINAL SURGERY
fascicolo: 3, volume: 5, anno: 2001,
pagine: 251 - 259
SICI:
1091-255X(200105/06)5:3<251:COEAPC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-GRADE DYSPLASIA; PHOTODYNAMIC THERAPY; DUODENOGASTROESOPHAGEAL REFLUX; GASTROESOPHAGEAL REFLUX; ACID SUPPRESSION; LASER-ABLATION; FOLLOW-UP; ADENOCARCINOMA; REGRESSION; MUCOSA;
Keywords:
Barrett's esophagus; antireflux surgery; endoscopic ablation; GERD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, KH Univ Wurzburg, Dept Surg, Inst Pathol, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 ny
Citazione:
H. Tigges et al., "Combination of endoscopic argon plasma coagulation and antireflux surgery for treatment of Barrett's esophagus", J GASTRO S, 5(3), 2001, pp. 251-259

Abstract

Columnar-lined epithelium with specialized intestinal metaplasia of the esophagus (i.e., Barrett's esophagus) is a premalignant condition caused by chronic gastroesophageal reflux disease. Progression of intestinal metaplasia may be avoided by antireflux surgery, whereas regeneration of esophageal mucosa could be achieved by endoscopic argon plasma coagulation (EAPC). Theaim of this prospective study was to show the early results of a combination of EAPC and antireflux surgery. Thirty patients with Barrett's esophaguswere treated between August 1996 and December 1999. Regeneration of esophageal mucosa was achieved with several sessions of EAPC under general anesthesia. All patients were receiving a double dose of proton pump inhibitors. Endoscopic follow-up was performed 6 to 8 weeks after the last session. Antireflux surgery(Nissen [n = 26] or Toupet [n = 4] fundoplication) followed complete regeneration of the squamous epithelium in the esophagus. One yearafter laparoscopic fundoplication and EAPC follow-up with endoscopy and quadrant biopsies of the esophagus, 24-hour pH monitoring and esophageal manometry were performed. All 30 patients showed complete regeneration of the squamous epithelium after a median of two sessions (range 1 to 7) of EAPC. Twenty-two patients underwent 1-year follow-up studies. All showed endoscopically an intact fundic wrap. Recurrence of a I cm segment of Barrett's epithelium without dysplasia was present in two patients, both of whom had recurrent acid reflux due to failure of their antireflux procedure. Our resultsindicate that the combination of EAPC and antireflux surgery is an effective treatment option in patients with Barrett's esophagus with gash oesophageal reflux disease. Long-term follow-up of this therapy is necessary to evaluate its effect on cancer risk in Barrett's esophagus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:21:40