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Titolo:
Sarcomere number regulation maintained after immobilization in desmin-nullmouse skeletal muscle
Autore:
Shah, SB; Peters, D; Jordan, KA; Milner, DJ; Friden, J; Capetanaki, Y; Lieber, RL;
Indirizzi:
Vet Affairs Med Ctr, Dept Orthopaed, Biomed Sci Grad Grp, La Jolla, CA 92161 USA Vet Affairs Med Ctr La Jolla CA USA 92161 rad Grp, La Jolla, CA 92161 USA Univ Calif San Diego, Dept Bioengn, Biomed Sci Grad Grp, La Jolla, CA 92161 USA Univ Calif San Diego La Jolla CA USA 92161 ad Grp, La Jolla, CA 92161 USA Univ Calif San Diego, Dept Orthopaed, Biomed Sci Grad Grp, La Jolla, CA 92161 USA Univ Calif San Diego La Jolla CA USA 92161 ad Grp, La Jolla, CA 92161 USA Vet Affairs Med Ctr, Dept Bioengn, Biomed Sci Grad Grp, La Jolla, CA 92161USA Vet Affairs Med Ctr La Jolla CA USA 92161 Grad Grp, La Jolla, CA 92161USA Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Cell Biol, Houston, TX 77030 USA Sahlgrens Univ Hosp, Dept Hand Surg, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
JOURNAL OF EXPERIMENTAL BIOLOGY
fascicolo: 10, volume: 204, anno: 2001,
pagine: 1703 - 1710
SICI:
0022-0949(200105)204:10<1703:SNRMAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENTS; SOLEUS MUSCLE; LONGITUDINAL GROWTH; AVIAN ERYTHROCYTES; DIFFERENT LENGTHS; SATELLITE CELLS; MESSENGER-RNA; UP-REGULATION; MYOD FAMILY; WILD-TYPE;
Keywords:
sarcomerogenesis; atrophy; intermediate filament; muscle architecture; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Lieber, RL Vet Affairs Med Ctr, Dept Orthopaed, Biomed Sci Grad Grp, La Jolla, CA 92161 USA Vet Affairs Med Ctr La Jolla CA USA 92161 Jolla, CA 92161 USA
Citazione:
S.B. Shah et al., "Sarcomere number regulation maintained after immobilization in desmin-nullmouse skeletal muscle", J EXP BIOL, 204(10), 2001, pp. 1703-1710

Abstract

The serial sarcomere number of skeletal muscle changes in response to chronic length perturbation. The role of the intermediate filament desmin in regulating these changes was investigated by comparing the architectural adaptations of the tibialis anterior, extensor digitorum longus (EDL) and soleus from wild-type mice with those of homozygous desmin knockout mice after hindlimb inmobilization. After 28 days, serial sarcomere number increased significantly in the lengthened wild-type tibialis anterior (by approximately9 %) and EDL (by approximately 17 %). Surprisingly, muscles from desmin knockout mice also experienced significant serial remodeling, with the serialsarcomere number of the tibialis anterior increasing by approximately 10 %and that of the EDL by approximately 27 %. A consistent result was observed in the shortened soleus: a significant decrease in sarcomere number was observed in the muscles from both wild-type (approximately 26%) and knockout(approximately 12 %) mice. Thus, although desmin is not essential for sarcomerogenesis or sarcomere subtraction in mouse hindlimb muscles, the results do suggest subtle differences in the nature of sarcomere number adaptation. We speculate that desmin may play a role in regulating the optimal arrangement of sarcomeres within the muscle or in sensing the magnitude of the immobilization effect itself.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 18:37:08