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Titolo:
Transport of bile acids in hepatic and non-hepatic tissues
Autore:
St-Pierre, MV; Kullak-Ublick, GA; Hagenbuch, B; Meier, PJ;
Indirizzi:
Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF EXPERIMENTAL BIOLOGY
fascicolo: 10, volume: 204, anno: 2001,
pagine: 1673 - 1686
SICI:
0022-0949(200105)204:10<1673:TOBAIH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC ANION TRANSPORTER; SALT EXPORT PUMP; MULTIDRUG-RESISTANCE PROTEIN; FAMILIAL INTRAHEPATIC CHOLESTASIS; ATP-DEPENDENT TRANSPORT; CANALICULAR MEMBRANE-VESICLES; CHOROID-PLEXUS EPITHELIUM; KIDNEY PROXIMAL TUBULES; RAT-LIVER; STEROL 27-HYDROXYLASE;
Keywords:
bile acid; liver; cholesterol; transporter; organic anion transport; carrier proteins; bile;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: St-Pierre, MV Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 h, Switzerland
Citazione:
M.V. St-Pierre et al., "Transport of bile acids in hepatic and non-hepatic tissues", J EXP BIOL, 204(10), 2001, pp. 1673-1686

Abstract

Bile acids are steroidal amphipathic molecules derived from the catabolismof cholesterol. They modulate bile flow and lipid secretion, are essentialfor the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bite ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across themembranes of the enterohepatic tissues. Individual bile acid carriers havenow been cloned from several species. Na+-dependent transporters that mediate uptake into hepatocytes and reabsorption from the intestine and biliaryepithelium and an ATP-dependent transporter that pumps bile acids into bile comprise the classes of transporter that are specific for bile acids. In addition, at least four human and five rat genes that code for Na+-independent organic anion carriers with broad multi-substrate specificities that include bile acids have been discovered. Studies concerning the regulation ofthese carriers have permitted identification of molecular signals that dictate eventual changes in the uptake or excretion of bile acids, which in turn have profound physiological implications. This overview summarizes and compares all known bile acid transporters and highlights findings that have identified diseases linked to molecular defects in these carriers, Recent advances that have fostered a more complete appreciation for the elaborate disposition of bile acids in humans are emphasized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:14:33